Table 1 Results of follow-up: Women without cancer before and at first (prevalence) control.
From: High penetrances of BRCA1 and BRCA2 mutations confirmed in a prospective series
Mutation group | Age group | n | Observation years | Cases with prospective cancer | Mean observation time | Annual incidence rate |
|---|---|---|---|---|---|---|
B1F | <40 | 195 | 1282 | 27 | 6.6 | 2.1% |
40-59 | 121 | 749 | 30 | 6.2 | 4.0% | |
60+ | 19 | 121 | 2 | 6.4 | 1.7% | |
SUM | 335 | 2152 | 59 | 6.4 | 2.7% | |
B1NF | <40 | 119 | 721 | 18 | 6.1 | 2.5% |
40-59 | 62 | 320 | 19 | 5.2 | 5.9% | |
60+ | 10 | 60 | 3 | 6.0 | 5.0% | |
SUM | 191 | 1101 | 40 | 5.8 | 3.6% | |
B2 | <40 | 64 | 347 | 5 | 5.4 | 1.4% |
40-59 | 51 | 258 | 9 | 5.1 | 3.5% | |
60+ | 8 | 29 | 2 | 3.6 | 6.9% | |
SUM | 123 | 634 | 16 | 5.2 | 2.5% | |
ALL | SUM | 649 | 3887 | 115 | 6.0 | 3.0% |