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Table 2 The five MUTYH variants and their association with endometrial cancer risk

From: Genetic variants in MUTYH are not associated with endometrial cancer risk

Polymorphisms Genotype Cases n (%) Controls n (%) X2 OR (95% CI) and p value
MUTYH Y165C (A>G) AA 190 (99.5) 120 (100)   1.00 (reference)
  AG 1 90.5) 0 (0.0) P = 0.43 0.53 (0.02–13.1) p = 0.43
  GG 0 (0.0) 9 (0.0)   
MUTYH G382D (G>A) GG 189 (99.0) 118 (98.3)   1.00 (reference)
  GA 2 (1.0) 2 (1.7) p = 0.6 41.6 (0.22–11.5) p = 0.63
  AA 0 (0.0) 0 (0.0)   
MUTYH V22M (G>A) GG 172 (90.1) 194 (85.8)   1.00 (reference)
  GA 17 (8.9) 31 (13.7)   1.62 (0.86–3.02) p = 0.17
  AA 2 (1.0) 1 (0.4)   0.44 (0.04–4.94) p = 0.92
MUTYH Q324H (G>C) GG 109 (57.1) 129 (59.2)   1.00 (reference)
  GC 71 (37.2) 75 (34.4) p = 0.83 0.89 (0.59–1.35) p = 0.66
  CC 11 (5.8) 14 (6.4)   1.08 (0.4&-2.47) p = 0.86
MUTYH S501F (C>T) CC 187 (97.9) 210 (96.8)   1.00 (reference)
  CT 4 (2.1) 7 (3.2) p = 0.48 1.56 (0.45–5.41) p = 0.69
  TT 0 (0.0) 0 (0.0)