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Table 3 Hazard Ratio and 95% Confidence Interval Estimates.

From: Penetrance of HNPCC-related cancers in a retrolective cohort of 12 large Newfoundland families carrying a MSH2 founder mutation: an evaluation using modified segregation models

 

Group

Age 30 (95% CI)

Age 50 (95% CI)

Age 70 (95% CI)

Any HNPCC cancer (Weibull)

    
 

Male

9.7 (0.3, 23.8)

9.7 (0.3, 23.8)

9.7 (0.3, 23.8)

 

Female

54.8 (4.4, 379.8)

54.8 (4.4, 379.8)

54.8 (4.4, 379.8)

CRC (Log logistic)

    
 

Male

34.1 (7.1, 167.0)

15.1 (3.9, 110.2)

6.8 (2.3, 66.2)

 

Female

37.7 (7.5, 176.9)

32.2 (6.9, 162.1)

23.7 (5.6, 137.9)

  1. Hazard ratio estimates at ages 30, 50 and 70 in mutation carriers compared with mutation non-carriers by sex, with corresponding 95% confidence intervals. Estimates based on the specified hazard function for age at diagnosis of any hereditary nonpolyposis colorectal cancer and colorectal cancer
  2. HNPCC = hereditary nonpolyposis colorectal cancer
  3. CRC = colorectal cancer
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287