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Table 2 Penetrance and 95% Confidence Interval Estimates.

From: Penetrance of HNPCC-related cancers in a retrolective cohort of 12 large Newfoundland families carrying a MSH2 founder mutation: an evaluation using modified segregation models

Group

Age 30 (95% CI)

Age 50 (95% CI)

Age 70 (95% CI)

Any HNPCC cancer (Weibull)

   

Male Carrier

9.1 (6.0, 17.9)

70.5 (59.1, 87.7)

98.2 (93.8, 99.9)

Female Carrier

6.1 (3.8, 11.6)

55.3 (42.8, 73.1)

92.8 (82.4, 99.1)

Male Non-carrier

1.0 (0.0, 1.6)

11.9 (0.2, 20.0)

33.9 (0.5, 53.6)

Female Non-carrier

0.1 (0.0, 1.4)

1.5 (0.1, 18.2)

4.7 (0.4, 49.8)

CRC (Log-logistic)

   

Male Carrier

11.1 (3.9, 19.9)

62.2 (38.4, 73.8)

84.5 (67.3, 91.3)

Female Carrier

1.4 (0.6, 3.7)

16.1 (8.9, 30.5)

38.9 (24.2, 62.1)

Male Non-carrier

0.3 (0.0, 1.6)

4.1 (0.6, 16.2)

12.5 (2.0, 39.8)

Female Non-carrier

0.0 (0.0, 0.3)

0.5 (0.1, 2.9)

1.6 (0.3, 9.3)

EC (Log-logistic)

   

Female Carriers

0.7

37.1

82.4

Female Non-carriers

0.0

0.0

0.0

  1. Penetrance estimates (percent) at ages 30, 50 and 70 by carrier status and sex, with corresponding 95% confidence intervals. Estimates based on the specified hazard function for age at diagnosis of any hereditary nonpolyposis colorectal cancer (any HNPCC cancer), colorectal cancer (CRC) and endometrial cancer (EC)