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Table 1 Description of NL Family Data Set.

From: Penetrance of HNPCC-related cancers in a retrolective cohort of 12 large Newfoundland families carrying a MSH2 founder mutation: an evaluation using modified segregation models

Group

Any HNPCC† cancer

CRC‡

ECΔ

 

Events

n

Events

n

Events

n

Males

      

Carriers*

34

71

32

71

-

-

Non-carriers

2

51

1

51

-

-

Unknowns

15

43

9

53

-

-

Females

      

Carriers*

38

74

16

74

16

73

Non-carriers

1

51

0

51

0

51

Unknowns

9

23

4

32

1

22

Family Members with Phenotype Information

 

313

 

332

 

146

  1. Number of each phenotype per subgroup based on sex and mutation status
  2. * includes known carriers and presumed carriers, n = number of relatives
  3. † HNPCC = hereditary nonpolyposis colorectal cancer
  4. ‡ CRC = colorectal cancer, Δ EC = endometrial cancer
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287