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Table 4 Estimated hazard ratios of colorectal cancer risk at ages 30, 50 and 70 (and corresponding 95% confidence interval) in gene mutation carriers (any MMR, MLH1, MSH2) compared with that in the general population, based on the segregation analysis.

From: Penetrance of colorectal cancer among MLH1/MSH2 carriers participating in the colorectal cancer familial registry in Ontario

Mutation Age 30 Age 50 Age 70
Any MMR 10.5 (2.5, 46.9) 8.8 (2.3, 40.1) 5.5 (1.8, 25.0)
MLH1 5.5 (0.8, 53.6) 6.5 (1.4, 41.8) 5.1 (1.3, 26.9)
MSH2 13.1 (0.3, 78.8) 9.3 (0.3, 44.4) 5.4 (0.3, 24.5)