Table 4 Estimated hazard ratios of colorectal cancer risk at ages 30, 50 and 70 (and corresponding 95% confidence interval) in gene mutation carriers (any MMR, MLH1, MSH2) compared with that in the general population, based on the segregation analysis.
Mutation | Age 30 | Age 50 | Age 70 |
|---|---|---|---|
Any MMR | 10.5 (2.5, 46.9) | 8.8 (2.3, 40.1) | 5.5 (1.8, 25.0) |
MLH1 | 5.5 (0.8, 53.6) | 6.5 (1.4, 41.8) | 5.1 (1.3, 26.9) |
MSH2 | 13.1 (0.3, 78.8) | 9.3 (0.3, 44.4) | 5.4 (0.3, 24.5) |