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Table 3 Estimates of cumulative risks (%) at ages 30, 50 and 70 (and corresponding 95% confidence intervals) for colorectal cancer among mutation carriers and non-carriers (any MMR, MLH1, MSH2) based on the segregation analysis.

From: Penetrance of colorectal cancer among MLH1/MSH2 carriers participating in the colorectal cancer familial registry in Ontario

Mutation Gender Age 30 Age 50 Age 70
Carrier of any MMR mutation Male 1 (0, 2) 23 (10, 33) 60 (35, 73)
  Female 1 (0, 1) 15 (7, 23) 47(27, 60)
  Combined 1 (0, 1) 18 (11, 25) 53 (37, 64)
MLH1 Carrier Male 1 (0, 2) 25 (7, 51) 67 (27, 89)
  Female 0 (0, 1) 8 (2, 19) 35 (10, 59)
  Combined 0 (0, 12) 13 (4, 30) 44 (19, 70)
MSH2 Carrier Male 1 (0, 2) 21 (1, 36) 55 (2, 75)
  Female 1 (0, 2) 20 (1, 32) 53 (2, 70)
  Combined 1 (0, 2) 20 (1, 29) 54 (3, 69)
Non-carrier of all mutations Male 0 (0, 1) 2 (0, 7) 10 (1, 27)
  Female 0 (0, 1) 1 (0, 6) 6 (1, 24)
  Combined 0 (0, 1) 2 (0, 6) 9 (2, 24)