Table 3 Estimates of cumulative risks (%) at ages 30, 50 and 70 (and corresponding 95% confidence intervals) for colorectal cancer among mutation carriers and non-carriers (any MMR, MLH1, MSH2) based on the segregation analysis.
Mutation | Gender | Age 30 | Age 50 | Age 70 |
|---|---|---|---|---|
Carrier of any MMR mutation | Male | 1 (0, 2) | 23 (10, 33) | 60 (35, 73) |
Female | 1 (0, 1) | 15 (7, 23) | 47(27, 60) | |
Combined | 1 (0, 1) | 18 (11, 25) | 53 (37, 64) | |
MLH1 Carrier | Male | 1 (0, 2) | 25 (7, 51) | 67 (27, 89) |
Female | 0 (0, 1) | 8 (2, 19) | 35 (10, 59) | |
Combined | 0 (0, 12) | 13 (4, 30) | 44 (19, 70) | |
MSH2 Carrier | Male | 1 (0, 2) | 21 (1, 36) | 55 (2, 75) |
Female | 1 (0, 2) | 20 (1, 32) | 53 (2, 70) | |
Combined | 1 (0, 2) | 20 (1, 29) | 54 (3, 69) | |
Non-carrier of all mutations | Male | 0 (0, 1) | 2 (0, 7) | 10 (1, 27) |
Female | 0 (0, 1) | 1 (0, 6) | 6 (1, 24) | |
Combined | 0 (0, 1) | 2 (0, 6) | 9 (2, 24) |