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Table 2 Estimates of cumulative risks (%) to ages 30, 50, and 70 (and corresponding 95% confidence intervals) for colorectal cancer stratified by MMR mutation status and gender using Kaplan-Meier analysis

From: Penetrance of colorectal cancer among MLH1/MSH2 carriers participating in the colorectal cancer familial registry in Ontario

Mutation Gender Age 30 Age 50 Age 70
Carrier of any MMR mutation Carrier Male
(n = 27)
- 21 (0, 39) 67 (3, 89)
  Female
(n = 33)
4 (0, 10) 35 (6, 55) 51 (16, 71)
  Combined
(n = 60)
2 (0, 6) 29 (10, 44) 55 (28, 72)
MLH1 carrier Male
(n = 13)
- 40 (0, 70) 70 (0, 94)
  Female
(n = 12)
- - 38 (0, 68)
  Combined
(n = 25)
- 16 (0, 34) 50 (4, 73)
MSH2 carrier Male
(n = 12)
- - -
  Female
(n = 23)
5 (0, 15) 61 (9, 83) 61 (9, 83)
  Combined
(n = 35)
3 (0, 10) 36 (6, 56) 56 (15, 77)
Non-carrier of all mutations Male
(n = 22)
- - -
  Female
(n = 40)
- 7 (0, 19) 7 (0, 19)
  Combined
(n = 62)
- 4 (0, 11) 4 (0, 11)
Any mutation unknown Male
(n = 195)
2 (0, 5) 23 (14, 31) 46 (34, 57)
  Female
(n = 157)
4 (0, 7) 13 (6, 20) 41 (27, 52)
  Combined
(n = 352)
3 (1, 5) 19 (13, 24) 44 (35, 52)
  1. (n represents the number of kin with blood available and age information available)