Table 4 Published results from various Indian groups on BRCA1 and BRCA2 mutation status on hereditary breast and ovarian cancer families or early onset breast cancer cases
From: Molecular genetics analysis of hereditary breast and ovarian cancer patients in India
Total No. cases | Gene(s) | Mutation detected | Authors and Year |
|---|---|---|---|
14 cases with F/H of BC & OC | BRCA1 | 3/14 (21%) | Kumar et al (2002) |
20 cases with F/H of B & OC or early onset (< 35 y) | BRCA1 &BRCA2 | 2/20 (10%) (BRCA1) | Saxsena et al 2002 |
24 cases with F/H of breast cancer and 100 sporadic cases | BRCA 1 &BRCA2 | 6/24 (25%) (BRCA1) | Hedau el at 2004 |
16 cases F/H of BC & OC and 20 sporadic cases | BRCA1 &BRCA2 | 5/16 (31%) (BRCA1 &BRCA2) | Valarmathi et al 2004 |
23 cases with F/H of BC & OC | BRCA1 | 1/23 | Gajalakshmi et al 2006 |
204 cases, 34 with F/H, 105 early onset (<40 y) and 65 late onset | BRCA1 &BRCA2 | 6/204 (2.9) (BRCA1 &BRCA2) except for one mutation were seen either in early onset cases or with F/H | Saxena et al 2006 |
91 cases, 54 with F/H of BC & OC, 34 early onset (≤ 35 y for BC and ≤ 40 y for OC); 3 HBOC in same individual | BRCA1 &BRCA2 | 15/91 (16%) (BRCA1 &BRCA2) | Current study |