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Table 1 Diagnostic criteria of HNPCC according to ICG-HNPCC [11]

From: Lynch syndrome (HNPCC)

1. At least 3 relatives are affected by histologically verified CRC or cancer of the endometrium, small bowel or urinary tract; at least one of them is a first degree relative of the other two; FAP is excluded*
2. At least 2 of the above persons are first degree relatives from Two different generations
3. At least 1 of the above persons has cancer diagnosed at age under 50 years
All other parameters (right side localization, syn- or metachronous tumours) should be treated as non-diagnostic features.
  1. *Colorectal polyposis, congenital hypertrophy of the retinal pigment epithelium, cysts and osteomas of the mandible/maxilla and desmoids are excluded