Table 1 Diagnostic criteria of HNPCC according to ICG-HNPCC [11]

1. At least 3 relatives are affected by histologically verified CRC or cancer of the endometrium, small bowel or urinary tract; at least one of them is a first degree relative of the other two; FAP is excluded*

2. At least 2 of the above persons are first degree relatives from Two different generations

3. At least 1 of the above persons has cancer diagnosed at age under 50 years

All other parameters (right side localization, syn- or metachronous tumours) should be treated as non-diagnostic features.