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Table 5 Options of control examinations for carriers of moderate cancer risk gene mutations

From: Hereditary breast and ovarian cancer

Organ

Examination

Age of beginning

(years)

Frequency

CHEK2 (1100delC, IVS2+1G>A, del5395), NBS1 (657del5), NOD2 (3020insC), CDKN2A (A148T)

self examination

20

every month

 

medical palpation

20-25

every 6 months

 

USG

25

every 12 months

(6 months after mammography)

BRCA2 (5972C/T), CYP1B1 (homozygote GTC)

mammography

35

every 12 months

CHEK2 (I157T)

self examination

20

every month

 

medical palpation

40

every 6 months

 

USG

40

every 12 months

(6 months after mammography)

 

MRI

40

every 12 months

 

mammography

40

every 12 months