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Table 5 Options of control examinations for carriers of moderate cancer risk gene mutations

From: Hereditary breast and ovarian cancer

Organ Examination Age of beginning
(years)
Frequency
CHEK2 (1100delC, IVS2+1G>A, del5395), NBS1 (657del5), NOD2 (3020insC), CDKN2A (A148T) self examination 20 every month
  medical palpation 20-25 every 6 months
  USG 25 every 12 months
(6 months after mammography)
BRCA2 (5972C/T), CYP1B1 (homozygote GTC) mammography 35 every 12 months
CHEK2 (I157T) self examination 20 every month
  medical palpation 40 every 6 months
  USG 40 every 12 months
(6 months after mammography)
  MRI 40 every 12 months
  mammography 40 every 12 months