Table 1 Pedigree-clinical diagnostic criteria of HBC-ss, HBOC and HOC syndromes [6]

A - 3 (definitive diagnosis)

   1) At least 3 relatives affected with breast or ovarian cancer diagnosed at any age

B - 2 (highly probable diagnosis)

   1) 2 breast or ovarian cancer cases among first degree relatives (or second degree through male line)

   2) 1 breast cancer and 1 ovarian cancer diagnosed at any age among first degree relatives (or second degree through male line)

C - 1 (highly probable diagnosis)

   1) Breast cancer diagnosed below 40 years of age

   2) Bilateral breast cancer

   3) Medullary or atypical medullary breast cancer

   4) Breast and ovarian cancer in the same person

   5) Breast cancer in male