From: DNA and RNA analyses in detection of genetic predisposition to cancer
Gene localization | Predisposition to malignancies | Penetrance* | Number of exons |
---|---|---|---|
Rb[2] 13q14 | retinoblastoma | about 90% | 27 exons |
BRCA1[3] 17q21 | cancers of the breast ovaries prostate colon | about 80% | 24 exons, 2 transcripts differing by first exon, 1863 amino acids |
BRCA2 | 27 exons | ||
13q | 3418 amino acids | ||
VHL[4] | haemangioblastoma of the cerebellum and retina | about 80% | 3 exons |
3p25-26 | kidney cancer | 213 amino acids | |
pheochromocytoma | |||
MSH2[5] | colon cancer | about 90% | 16 exons |
2p22 | endometrial cancer | for male | 934 amino acids |
MLH1 3p22-23 | cancer of the stomach, small bowel, biliary tract, ovary | about 70% for female[6] | 19 exons 756 amino acids |
MSH6 | 10 exons | ||
2p16 | 1361 amino acids |