Thyroid cancer in a patient with a germline MSH2 mutation. Case report and review of the Lynch syndrome expanding tumour spectrum

Table 1 Lynch syndrome tumour spectrum. Cumulative risks and average ages at diagnosis

Tumour site	MLH1		MSH2		MSH6
	male	female	male	female	male	female
Colorectum	22-65% (41-47 years)	18-54% (41-47 years)	30-73% (44-46 years)	25-54% (44-46 years)	60-70% (50-54 years)	30-40% (50-54 years)
Endometrium		25-65% (59 year)		22-61% (59 year)		60-70% (54 year)
Small intestine	7%		4%		n.a.
Stomach	2%		4%		n.a.
Ovary	3%		10%		10-28%
Ureter and renal pyelum	1%		12%		n.a.
Brain	n.a.		1%		n.a.
Sebaceous glands Pancreas Biliary tract	n.a.		n.a.		n.a.

n.a. - not available
Shown in brackets are the ranges of average ages at diagnosis. For the PMS2 gene no cumulative risks are available.
Modified from a table developed by D Voskuil and RH Sijmons for the Dutch National Guidelines on Hereditary Colorectal Cancer (Menko F, ed. Richtlijn Erfelijke Darmkanker, VKGN, VIKC and CBO, 2007), used with permission

ISSN: 1897-4287