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Table 1 Revised Bethesda guidelines (Umar et al. 2004)

From: Abstracts from the 11th Annual Meeting of the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC), October 21–22, 2007, La Jolla, California, USA

Requires at least one of the following in an individual being evaluated:

   (I) Colorectal cancer diagnosed prior to age 50

   (II) Presence of two primary Lynch syndrome-associated tumors*

   (III) Colorectal cancer diagnosed less than 60 years of age with MSI-high histology

   (IV) Colorectal cancer and one or more first degree relatives with a Lynch syndrome-associated tumor*, with at least one of the cancers being diagnosed under age 50 years

   (V) Colorectal cancer and two or more first or second degree relatives with a Lynch syndrome-associated tumor*, regardless of age

  1. *colorectal, endometrial, stomach, ovarian, pancreas, sebaceous gland, ureter, renal pelvis, and biliary tract cancer, keratocanthoma, glioblastoma, and carcinoma of the small bowel