Requires at least one of the following in an individual being evaluated: |
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(I) Colorectal cancer diagnosed prior to age 50 |
(II) Presence of two primary Lynch syndrome-associated tumors* |
(III) Colorectal cancer diagnosed less than 60 years of age with MSI-high histology |
(IV) Colorectal cancer and one or more first degree relatives with a Lynch syndrome-associated tumor*, with at least one of the cancers being diagnosed under age 50 years |
(V) Colorectal cancer and two or more first or second degree relatives with a Lynch syndrome-associated tumor*, regardless of age |