Location or type of tumour | Number of tested | Number of mutation carriers (frequency), results of statistical analysis* | |||
---|---|---|---|---|---|

IVS2+1G>A | 1100delC | 1100delC or IVS2+1G>A | I157T | ||

Bladder | 172 | 1 (0.6%) | 1 (0.6%) | 12 (7.0%) | |

OR = 1.2 | 0 | OR = 0.8 | OR = 1.5 | ||

p = 0.7 | p = 0.8 | p = 0.3 | |||

Kidney | 264 | 0 | 2 (0.8%) | 2 (0.8%) | 26 (9.8%) |

OR = 2.7 | OR = 1.0 | OR = 2.1 | |||

p = 0.5 | p = 0.8 | p = 0.0006 | |||

Larynx | 245 | 0 | 0 | 0 |
10 (4.1%) OR = 0.8 p = 0.7 |

Lung | 272 | 0 | 0 | 0 |
7 (2.6%) OR = 0.5 p = 0.1 |

Melanoma | 129 |
2 (1.5%) OR = 3.3 p = 0.3 |
1 (0.8%) OR = 3.1 p = 0.8 |
3 (2.3%) OR = 3.2 p = 0.1 |
6 (4.6%) OR = 1.0 p = 0.9 |

Ovary | 292 | 0 | 0 | 0 |
14 (4.8%) OR = 1.0 p = 0.9 |

Stomach | 241 |
4 (1.7%) OR = 3.5 p = 0.05 | 0 |
4 (2.1%) OR = 2.3 p = 0.2 |
13 (5.4%) OR = 1.1 p = 0.8 |

NHL | 120 |
1 (0.8%) OR = 1.8 p = 0.9 | 0 |
1 (0.8%) OR = 1.1 p = 0.7 |
11 (9.2%) OR = 2.0 p = 0.05 |

Pancreas | 93 | 0 | 0 | 0 |
6 (6.4%) OR = 1.4 p = 0.6 |

Thyroid | 173 |
5 (2.9%) OR = 6.2 p = 0.0003 |
1 (0.6%) OR = 2.3 p = 0.9 |
6 (3.5%) OR = 4.9 p = 0.0006 |
15 (8.7%) OR = 1.9 p = 0.04 |

Controls | 4000 | 19 (0.475%) | 10 (0.25%) | 29 (0.725%) | 193 (4.825%) |