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Table 2 Comparison of the frequency of BRCA1 mutations in 1793 patients with prostate cancer and 4570 controls

From: Selected aspects of inherited susceptibility to prostate cancer and tumours of different site of origin

Mutation

Number of carriers (frequency)

OR

95% CI

p

 

cases (n = 1793)

controls (n = 4570)

   
 

No. (%)

No. (%)

   

BRCA1

8 (0.45)

22 (0.48)

0.9

0.4–2.1

1.0

C61G

3 (0.17)

3 (0.07)

2.6

0.5–12.7

0.5

4153delA

4 (0.22)

2 (0.04)

5.1

0.9–27.9

0.1

5382insC

1 (0.06)

17 (0.37)

0.15

0.02–1.1

0.06

C61G or 4153delA*

7 (0.39)

5 (0.11)

3.6

1.1–11.3

0.045

  1. CI – confidence interval; OR – odds ratio; p – p-value
  2. *when 5382insC is excluded, as unlikely pathogenic for prostate cancer in the Polish population
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287