Table 1 Comparison of the frequency of variants in RNASEL and MSR1 genes in 737 patients with prostate cancer and 511 individuals from control group
Gene | Variant | Genotype | Number of carriers (frequency) | OR | 95% CI | p | |
|---|---|---|---|---|---|---|---|
| Â | Â | Â | cases (n = 737) No. (%) | controls (n = 511) No. (%) | Â | Â | Â |
RNASEL | 1385G>A (R462Q) | GG | 245 (33.3) | 177 (34.6) | 0.9 | 0.7–1.2 | 0.6 |
|  |  | GA | 376 (51.0) | 252 (49.3) | 1.1 | 0.9–1.3 | 0.6 |
|  |  | AA | 116 (15.7) | 82 (16.1) | 1.0 | 0.7–1.3 | 0.9 |
|  | 1623T>G (D541E) | TT | 111 (15.1) | 84 (16.4) | 0.9 | 0.7–1.2 | 0.5 |
|  |  | TG | 372 (50.5) | 259 (50.7) | 1.0 | 0.8–1.2 | 1.0 |
|  |  | GG | 254 (34.4) | 168 (32.9) | 1.1 | 0.8–1.4 | 0.6 |
MSR1 | 945C>G (P275A) | CC | 663 (90.0) | 474 (92.8) | 0.7 | 0.5–1.1 | 0.1 |
|  |  | CG | 74 (10.0) | 37 (7.2) | 1.4 | 0.9–2.2 | 0.1 |
|  | 999C>T (R293X) | CC | 725 (98.4) | 503 (98.4) | 1.0 | 0.4–2.4 | 1.0 |
|  |  | CT | 12 (1.6) | 8 (1.6) | 1.0 | 0.4–2.6 | 1.0 |