Skip to main content

Table 9 Occurrence of melanoma and breast cancer among first-degree relatives of MM probands

From: Some Molecular and Clinical Aspects of Genetic Predisposition to Malignant Melanoma and Tumours of Various Site of Origin

Feature R160W p 95% CI OR
first-degree relatives affected with carriers (+)n = 85 non-carriers (-)n = 373    
melanoma3 4 (4.7%)1 17 (4.5%)2 n.s. - -
breast cancer4 4 (4.7%) 25 (6.7%) n.s. - -
R151C
  carriers (+)n = 74 non-carriers (-)n = 401    
melanoma 7 (9.5%) 11 (2.7%) 0.0097 1.276–9.061 3.4
breast cancer 5 (6.7%) 25 (6.2%) n.s. - -
V60L
  carriers (+) non-carriers (-)    
  n = 78 n = 354    
melanoma 5 (6.4%) 10 (2.8%) n.s. - 2.4
breast cancer 5 (6.4%) 24 (6.7%) n.s. - -
R163Q
  carriers (+)n = 30 non-carriers (-)n = 354    
melanoma 1 (3.3%) 13 (3.6%) n.s - -
breast cancer 2 (5%) 17 (4.8%) n.s - -
  any of four variants positive none of four variants positive    
  carriers (+) non-carriers (-)    
  n = 245 n = 149    
melanoma 17 (6.9%) 3 (2.0%) 0.03 1.05–12.60 3.6
breast cancer 16 (6.5%) 8 (5.4%) n.s - -
  1. 1percentage of carriers with at least one affected first-degree relative
  2. 2percentage of probands without MC1R variants but with at least one affected first-degree relative
  3. 3number of melanoma cases among first-degree relatives
  4. 4number of breast cancer cases among first-degree relatives