Some Molecular and Clinical Aspects of Genetic Predisposition to Malignant Melanoma and Tumours of Various Site of Origin

Table 9 Occurrence of melanoma and breast cancer among first-degree relatives of MM probands

Feature	R160W		p	95% CI	OR
first-degree relatives affected with	carriers (+)n = 85	non-carriers (-)n = 373
melanoma³	4 (4.7%)¹	17 (4.5%)²	n.s.	-	-
breast cancer⁴	4 (4.7%)	25 (6.7%)	n.s.	-	-
R151C
	carriers (+)n = 74	non-carriers (-)n = 401
melanoma	7 (9.5%)	11 (2.7%)	0.0097	1.276–9.061	3.4
breast cancer	5 (6.7%)	25 (6.2%)	n.s.	-	-
V60L
	carriers (+)	non-carriers (-)
	n = 78	n = 354
melanoma	5 (6.4%)	10 (2.8%)	n.s.	-	2.4
breast cancer	5 (6.4%)	24 (6.7%)	n.s.	-	-
R163Q
	carriers (+)n = 30	non-carriers (-)n = 354
melanoma	1 (3.3%)	13 (3.6%)	n.s	-	-
breast cancer	2 (5%)	17 (4.8%)	n.s	-	-
	any of four variants positive	none of four variants positive
	carriers (+)	non-carriers (-)
	n = 245	n = 149
melanoma	17 (6.9%)	3 (2.0%)	0.03	1.05–12.60	3.6
breast cancer	16 (6.5%)	8 (5.4%)	n.s	-	-

¹percentage of carriers with at least one affected first-degree relative
²percentage of probands without MC1R variants but with at least one affected first-degree relative
³number of melanoma cases among first-degree relatives
⁴number of breast cancer cases among first-degree relatives

ISSN: 1897-4287