Table 6 Association between A148T variants and selected types of cancer
Cases | A148T | OR | 95% confidence interval | p (adjusted) |
|---|---|---|---|---|
controls | 0 (0%) A/A | - | - | - |
(n = 3000) | 105 (3.5%) G/A | - | - | - |
| Â | 2895 (96.5%) G/G | - | - | - |
| Â | Allele A frequency 1.75% | - | - | - |
bladder | 0 (0%) A/A | - | - | - |
(n = 223) | 7 (3.1%) G/A | 0.9 | 0.4105–1.945 | 0.7764 (n.s.) |
|  | 216 (96.9%) G/G | 1.1 | 0.5142–2.436 | 0.7764 (n.s.) |
|  | Allele A frequency 1.6% | 0.9 | 0.4012–1.876 | 0.7177 (n.s.) |
colon | 0 (0%) A/A | - | - | - |
(n = 724) | 37 (5.1%) G/A | 1.5 | 1.012–2.180 | 0.0423 (0.5499) |
|  | 687 (94.9%) G/G | 0.7 | 0.459–0.989 | 0.0423 (0.5499) |
|  | Allele A frequency 2.6% | 1.5 | 1.008–2.151 | 0.0443 (0.5759) |
stomach | 0 (0%) A/A | - | - | - |
(n = 246) | 8 (3.3%) G/A | 0.9 | 0.4461–1.925 | 0.8384 (n.s.) |
|  | 238 (96.7%) G/G | 1.1 | 0.5194–2.241 | 0.8384 (n.s.) |
|  | Allele A frequency 1.6% | 0.9 | 0.4494–1.916 | 0.8398 (n.s.) |
larynx | 0 (0%) A/A | - | - | - |
(n = 396) | 17 (4.3%) G/A | 1.2 | 0.7326–2.088 | 0.4255 (n.s.) |
|  | 379 (95.7%) G/G | 0.8 | 0.4790–1.365 | 0.4255 (n.s.) |
|  | Allele A frequency 2.1% | 1.2 | 0.7337–2.067 | 0.4298 (n.s.) |
ovary | 0 (0%) A/A | - | - | - |
(n = 340) | 12 (3.5%) G/A | 1.0 | 0.5491–1.853 | 0.9777 (n.s.) |
|  | 328 (96.5%) G/G | 1.0 | 0.5396–1.821 | 0.9777 (n.s.) |
|  | Allele A frequency 1.8% | 1.0 | 0.5520–1.843 | 0.9779 (n.s.) |
lung | 0 (0%) A/A | - | - | - |
(n = 497) | 34 (6.8%) G/A | 2.0 | 1.358–3.018 | 0.0004 (0.0052) |
|  | 463 (93.2%) G/G | 0.5 | 0.331–0.736 | 0.0004 (0.0052) |
|  | Allele A frequency 3.4% | 2.0 | 1.342–2.945 | 0.0005 (0.0065) |
prostate | 0 (0%) A/A | - | - | - |
(n = 348) | 13 (3.7%) G/A | 1.1 | 0.5946–1.925 | 0.8215 (n.s.) |
|  | 335 (96.3%) G/G | 0.9 | 0.5194–1.682 | 0.8215 (n.s.) |
|  | Allele A frequency 1.9% | 1.1 | 0.5972–1.912 | 0.8231 (n.s.) |
kidney | 0 (0%) A/A | - | - | - |
(n = 264) | 6 (2.3%) G/A | 0.6 | 0.2788–1.474 | 0.2915 (n.s.) |
|  | 258 (97.7%) G/G | 1.6 | 0.6782–3.586 | 0.2915 (n.s.) |
|  | Allele A frequency 1.1% | 0.6 | 0.2820–1.477 | 0.2957 (n.s.) |
thyroid | 0 (0%) A/A | - | - | - |
(n = 173) | 3 (1.7%) G/A | 0.5 | 0.1528–1.549 | 0.2129 (n.s.) |
|  | 170 (98.3%) G/G | 2.1 | 0.6454–6.545 | 0.2129 (n.s.) |
|  | Allele A frequency 0.9% | 0.5 | 0.1550–1.556 | 0.2169 (n.s.) |
nonHodgkin | 0 (0%) A/A | - | - | - |
lymphoma | 6 (3.7%) G/A | 1.1 | 0.4585–2.453 | 0.8909 (n.s.) |
(n = 162) | 156 (96.3%) G/G | 0.9 | 0.4077–2.181 | 0.8909 (n.s.) |
|  | Allele A frequency 1.9% | 1.0 | 0.4616–2.431 | 0.8918 (n.s.) |
pancreas | 0 (0%) A/A | - | - | - |
(n = 210) | 8 (3.8%) G/A | 1.1 | 0.5246–2.273 | 0.8140 (n.s.) |
|  | 202 (96.2%) G/G | 0.9 | 0.4400–1.906 | 0.8140 (n.s.) |
|  | Allele A frequency 1.9% | 1.1 | 0.5275–2.253 | 0.8156 (n.s.) |