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Table 6 Association between A148T variants and selected types of cancer

From: Some Molecular and Clinical Aspects of Genetic Predisposition to Malignant Melanoma and Tumours of Various Site of Origin

Cases A148T OR 95% confidence interval p (adjusted)
controls 0 (0%) A/A - - -
(n = 3000) 105 (3.5%) G/A - - -
  2895 (96.5%) G/G - - -
  Allele A frequency 1.75% - - -
bladder 0 (0%) A/A - - -
(n = 223) 7 (3.1%) G/A 0.9 0.4105–1.945 0.7764 (n.s.)
  216 (96.9%) G/G 1.1 0.5142–2.436 0.7764 (n.s.)
  Allele A frequency 1.6% 0.9 0.4012–1.876 0.7177 (n.s.)
colon 0 (0%) A/A - - -
(n = 724) 37 (5.1%) G/A 1.5 1.012–2.180 0.0423 (0.5499)
  687 (94.9%) G/G 0.7 0.459–0.989 0.0423 (0.5499)
  Allele A frequency 2.6% 1.5 1.008–2.151 0.0443 (0.5759)
stomach 0 (0%) A/A - - -
(n = 246) 8 (3.3%) G/A 0.9 0.4461–1.925 0.8384 (n.s.)
  238 (96.7%) G/G 1.1 0.5194–2.241 0.8384 (n.s.)
  Allele A frequency 1.6% 0.9 0.4494–1.916 0.8398 (n.s.)
larynx 0 (0%) A/A - - -
(n = 396) 17 (4.3%) G/A 1.2 0.7326–2.088 0.4255 (n.s.)
  379 (95.7%) G/G 0.8 0.4790–1.365 0.4255 (n.s.)
  Allele A frequency 2.1% 1.2 0.7337–2.067 0.4298 (n.s.)
ovary 0 (0%) A/A - - -
(n = 340) 12 (3.5%) G/A 1.0 0.5491–1.853 0.9777 (n.s.)
  328 (96.5%) G/G 1.0 0.5396–1.821 0.9777 (n.s.)
  Allele A frequency 1.8% 1.0 0.5520–1.843 0.9779 (n.s.)
lung 0 (0%) A/A - - -
(n = 497) 34 (6.8%) G/A 2.0 1.358–3.018 0.0004 (0.0052)
  463 (93.2%) G/G 0.5 0.331–0.736 0.0004 (0.0052)
  Allele A frequency 3.4% 2.0 1.342–2.945 0.0005 (0.0065)
prostate 0 (0%) A/A - - -
(n = 348) 13 (3.7%) G/A 1.1 0.5946–1.925 0.8215 (n.s.)
  335 (96.3%) G/G 0.9 0.5194–1.682 0.8215 (n.s.)
  Allele A frequency 1.9% 1.1 0.5972–1.912 0.8231 (n.s.)
kidney 0 (0%) A/A - - -
(n = 264) 6 (2.3%) G/A 0.6 0.2788–1.474 0.2915 (n.s.)
  258 (97.7%) G/G 1.6 0.6782–3.586 0.2915 (n.s.)
  Allele A frequency 1.1% 0.6 0.2820–1.477 0.2957 (n.s.)
thyroid 0 (0%) A/A - - -
(n = 173) 3 (1.7%) G/A 0.5 0.1528–1.549 0.2129 (n.s.)
  170 (98.3%) G/G 2.1 0.6454–6.545 0.2129 (n.s.)
  Allele A frequency 0.9% 0.5 0.1550–1.556 0.2169 (n.s.)
nonHodgkin 0 (0%) A/A - - -
lymphoma 6 (3.7%) G/A 1.1 0.4585–2.453 0.8909 (n.s.)
(n = 162) 156 (96.3%) G/G 0.9 0.4077–2.181 0.8909 (n.s.)
  Allele A frequency 1.9% 1.0 0.4616–2.431 0.8918 (n.s.)
pancreas 0 (0%) A/A - - -
(n = 210) 8 (3.8%) G/A 1.1 0.5246–2.273 0.8140 (n.s.)
  202 (96.2%) G/G 0.9 0.4400–1.906 0.8140 (n.s.)
  Allele A frequency 1.9% 1.1 0.5275–2.253 0.8156 (n.s.)