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Table 3 Frequencies of CDKN2A variant alleles in cases and controls

From: Some Molecular and Clinical Aspects of Genetic Predisposition to Malignant Melanoma and Tumours of Various Site of Origin

Groups

A148T

OR 95% CI

Nt500c>g

OR 95% CI

Nt540c>t

OR 95% CI

newborns

0 (0%) A/A

-

6 (1.2%) G/G

-

4 (0.8%) T/T

-

(n = 500)

14 (2.8%) G/A

-

88 (17.6%) G/C

-

62 (12.4%) C/T

-

 

486 (97.2%) G/G

-

406 (81.2%) C/C

-

434 (86.8%) C/C

-

adults

0 (0%) A/A

-

9 (1.3%) G/G

-

3 (0.4%) T/T

-

(n = 710)

21 (2.95%) G/A

-

143 (20.1%) G/C

-

83 (11.7%) C/T

-

 

689 (97.05%) G/G

-

558 (78.6%) C/C

-

625 (88%) C/C

-

total controls

(n = 1210)

0 (0%) A/A

-

15 (1.2%) G/G

-

7 (0.6%) T/T

-

 

35 (2.89%) G/A

-

229 (18.9%) G/C

-

145 (12%) C/T

-

 

1175(97.1%)GG

-

966 (79.8%) C/C

-

1058(87.4%)C/C

-

 

Allel A 1.5%

-

Allel G 10.7%

-

Allel T 6.6%

-

MM*

0 (0%) A/A

-

8 (1.7%) G/G

1.44 0.6–3.3

3 (0.6%) T/T

1.14 0.3–4.3

(n = 471)

33 (7%) G/A

2.51 1.5–4.1

103 (21.9%) G/C

1.24 0.9–1.6

64 (13.5%) C/T

1.24 0.8–1.6

 

438 (93%) G/G

0.41 0.2–0.6

360 (76.4%) C/C

0.84 0.6–1.1

404 (85.7%) C/C

0.94 0.6–1.2

 

Allel A 3.5%

2.51 1.5–4.0

Allel G 12.6%

1.24 0.9–1.5

Allel T 7.4%

1.14 0.9–1.5

melanoma ≤ 50

(n = 172)

0 (0%) A/A

-

1 (0.6%) G/G

0.54 0.1–3.6

2 (1.2%) T/T

2.04 0.4–9.8

 

16 (9.3%) G/A

3.42 1.9–6.4

32 (18.6%) G/C

1.04 0.6–1.5

21 (12.2%) C/T

1.04 0.6–1.7

 

156 (90.7%) G/G

0.32 0.2–0.5

139 (80.8%) C/C

1.14 0.7–1.6

149 (86.6%) C/C

0.94 0.6–1.5

 

Allel A 4.7%

3.32 1.8–6.1

Allel G 9.9%

0.94 0.6–1.3

Allel T 7.3%

1.14 0.7–1.7

melanoma > 50

(n = 299)

0 (0%) A/A

-

7 (2.3%) G/G

1.94 0.8–4.7

1 (0.3%) T/T

0.64 0.1–4.7

 

17 (5.7%) G/A

2.03 1.1–3.7

71 (23.7%) G/C

1.34 1.0–1.8

43 (14.4%) C/T

1.24 0.9–1.8

 

282 (94.3%) G/G

0.53 0.3–0.9

221 (73.9%) C/C

0.74 0.5–0.9

255 (85.3%) C/C

0.84 0.6–1.2

 

Allel A 2.8%

2.03 1.1–3.6

Allel G 14.2%

1.44 1.0–1.8

Allel T 7.5%

1.24 0.8–1.6

  1. *unselected malignant melanomas;
  2. 1p = 0.0003, 2p = 0.0002, 3p = 0.0315, 4p ≥ 0.05 – not statistically significant