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Table 2 Results of statistical analyses (expected and observed frequency, related risk of occurrence of malignancies of various site of origin) in MM/CFA families

From: Some Molecular and Clinical Aspects of Genetic Predisposition to Malignant Melanoma and Tumours of Various Site of Origin

Tumour site1 Observed frequency (OF %) Expected frequency (EF %) Relative risk (RR, CI 95%)
breast 2    
   ≤ 55 MM/CFA 142 (10.6) 5.68 (4.3) 3.256 (CI 95% 0.95–6.8)4
   >55 MM/CFA 132 (9.8) 11.35 (8.6) 1.145 (CI 95% 0.54–2.45)
lungs    
   males 17 (5.6) 12.57 (4.1) 1.352 (CI 95% 0.63–2.934)
   females 4 (1.3) 2.95 (0.9) 1.358 (CI 95% 0.258–7.678)
colon    
   males 8 (2.6) 5.17 (1.7) 1.547 (CI 95% 0.47–5.306)
   females 7 (2.2) 4.59 (1.5) 1.526 (CI 95% 0.427–5.723)
stomach    
   males 5 (1.6) 3.11 (1.0) 1.609 (CI 95% 0.344–8.232)
   females 4 (1.3) 2.59 (0.8) 1.543 (CI 95% 0.278–9.577)
liver    
   males 4 (1.3) 2.24 (0.7) 1.786 (CI 95% 0.301–12.53)
   females 6 (1.9) 2.50 (0.8) 2.396 (CI 95% 0.497–13.83)
skin 3    
   males 5 (1.6) 3.41 (1.1) 1.465 (CI 95% 0.326–7.06)
   females 3 (1.0) 3.88 (1.2) 0.773 (CI 95% 0.137–4.107)
  1. 1breast cancer was studied in two separate groups, the remaining tumours in one group (51 families with MM/CFA)
  2. 2women only, 3 cases of bilateral or metachronic breast cancer and 1 case of breast cancer in a man were excluded from further study
  3. 3skin cancer (basocellular or spinocellular)
  4. 4p < 0.05