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Table 2 Results of statistical analyses (expected and observed frequency, related risk of occurrence of malignancies of various site of origin) in MM/CFA families

From: Some Molecular and Clinical Aspects of Genetic Predisposition to Malignant Melanoma and Tumours of Various Site of Origin

Tumour site1

Observed frequency (OF %)

Expected frequency (EF %)

Relative risk (RR, CI 95%)

breast 2

   

   ≤ 55 MM/CFA

142 (10.6)

5.68 (4.3)

3.256 (CI 95% 0.95–6.8)4

   >55 MM/CFA

132 (9.8)

11.35 (8.6)

1.145 (CI 95% 0.54–2.45)

lungs

   

   males

17 (5.6)

12.57 (4.1)

1.352 (CI 95% 0.63–2.934)

   females

4 (1.3)

2.95 (0.9)

1.358 (CI 95% 0.258–7.678)

colon

   

   males

8 (2.6)

5.17 (1.7)

1.547 (CI 95% 0.47–5.306)

   females

7 (2.2)

4.59 (1.5)

1.526 (CI 95% 0.427–5.723)

stomach

   

   males

5 (1.6)

3.11 (1.0)

1.609 (CI 95% 0.344–8.232)

   females

4 (1.3)

2.59 (0.8)

1.543 (CI 95% 0.278–9.577)

liver

   

   males

4 (1.3)

2.24 (0.7)

1.786 (CI 95% 0.301–12.53)

   females

6 (1.9)

2.50 (0.8)

2.396 (CI 95% 0.497–13.83)

skin 3

   

   males

5 (1.6)

3.41 (1.1)

1.465 (CI 95% 0.326–7.06)

   females

3 (1.0)

3.88 (1.2)

0.773 (CI 95% 0.137–4.107)

  1. 1breast cancer was studied in two separate groups, the remaining tumours in one group (51 families with MM/CFA)
  2. 2women only, 3 cases of bilateral or metachronic breast cancer and 1 case of breast cancer in a man were excluded from further study
  3. 3skin cancer (basocellular or spinocellular)
  4. 4p < 0.05