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Table 1 Proportion and age at diagnosis of malignancies of various site of origin in relatives of MM patients from MM/CFA families

From: Some Molecular and Clinical Aspects of Genetic Predisposition to Malignant Melanoma and Tumours of Various Site of Origin

Tumour site ≤ 55 MM/CFA families >55 MM/CFA families General population1
  frequency odds mean age frequency odds mean age frequency mean age
  (%) ratio at diagnosis (%) ratio at diagnosis (%) at diagnosis
breast 17 (17.52)3 2.14 48.473 13 (12.15) - 50.85 8.96 58.5
= 50 years 10 (10.3)3 3.71 - 8 (7.5)3 2.61 - 2.77 -
>50 years 7 (7.2) - - 5 (4.7) - - 6.19 -
lungs 11 (11.34) - 61.13 10 (9.34)3 - 62.23 19.15 64
colon 6 (6.19) - 65.4 9 (8.41) - 67.3 9.68 62
stomach 3 (3.09) - 61.9 6 (5.60) - 61.4 5.95 67
liver 4 (4.12) - 66.9 6 (6.54)3 - 67.7 1.77 67
skin4 3 (3.09) - 61.8 5 (4.67) - 62.1 4.47 67.6
leukaemia 3 (4.12) not done   0 not done   1.95 not done
CSU2 12 (12.38)3 not done   8 (7.47)3 not done   0.42 not done
  1. 1general Polish population (Zatoñski W, Tyczyñski J. Nowotwory w Polsce w 1999. Krajowy rejestr nowotworów, Warszawa 2001)
  2. 211 cases of ovarian, uterine or cervical cancer 6.1%, site of origin not confirmed
  3. 3p < 0.05, statistically significant
  4. 4skin cancers