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Table 1 Proportion and age at diagnosis of malignancies of various site of origin in relatives of MM patients from MM/CFA families

From: Some Molecular and Clinical Aspects of Genetic Predisposition to Malignant Melanoma and Tumours of Various Site of Origin

Tumour site

≤ 55 MM/CFA families

>55 MM/CFA families

General population1

 

frequency

odds

mean age

frequency

odds

mean age

frequency

mean age

 

(%)

ratio

at diagnosis

(%)

ratio

at diagnosis

(%)

at diagnosis

breast

17 (17.52)3

2.14

48.473

13 (12.15)

-

50.85

8.96

58.5

= 50 years

10 (10.3)3

3.71

-

8 (7.5)3

2.61

-

2.77

-

>50 years

7 (7.2)

-

-

5 (4.7)

-

-

6.19

-

lungs

11 (11.34)

-

61.13

10 (9.34)3

-

62.23

19.15

64

colon

6 (6.19)

-

65.4

9 (8.41)

-

67.3

9.68

62

stomach

3 (3.09)

-

61.9

6 (5.60)

-

61.4

5.95

67

liver

4 (4.12)

-

66.9

6 (6.54)3

-

67.7

1.77

67

skin4

3 (3.09)

-

61.8

5 (4.67)

-

62.1

4.47

67.6

leukaemia

3 (4.12)

not done

 

0

not done

 

1.95

not done

CSU2

12 (12.38)3

not done

 

8 (7.47)3

not done

 

0.42

not done

  1. 1general Polish population (Zatoñski W, Tyczyñski J. Nowotwory w Polsce w 1999. Krajowy rejestr nowotworów, Warszawa 2001)
  2. 211 cases of ovarian, uterine or cervical cancer 6.1%, site of origin not confirmed
  3. 3p < 0.05, statistically significant
  4. 4skin cancers
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287