Table 6 Genes commonly down-regulated 2-fold or more in desmoid tumours compared to normal fibroblast cells
From: Gene Expression Profiling in Familial Adenomatous Polyposis Adenomas and Desmoid Disease
Symbol | Gene Name |
|---|---|
Cell Cycle | Â |
GRN | Granulin |
QSCN6 | Quiescin Q6 |
STAT1 | Signal transducer and activator of transcription 1,91 kDa, tv-α |
STAT1 | Signal transducer and activator of transcription 1,91 kDa, tv-β |
TIMP1 | Tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) |
Transcription/Transcriptional Regulation | |
HIST1H2BK | Histone 1, H2bk |
LOXL1 | Lysyl oxidase-like 1 |
MSC | Musculin (activated B-cell factor-1) |
PRRX1 | Paired related homeobox 1, tv-pmx-1b |
ZDHHC14 | Zinc finger, DHHC domain containing 14 |
Transport | Â |
GLRB | Glycine receptor, beta |
PCOLCE2 | Procollagen C-endopeptidase enhancer 2 |
SCAMP3 | Secretory carrier membrane protein 3, tv-1 |
SLC31A2 | Solute carrier family 31 (copper transporters), member 2 |
Metabolism | Â |
AK1 | Adenylate kinase 1 |
AKR1C3 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) |
C1RL | Complement component 1, r subcomponent-like |
COMT | Catechol-O-methyltransferase, tv-MB-COMT |
CTSL | Cathepsin L, tv-2 |
GCLM | Glutamate-cysteine ligase, modifier subunit |
GNPDA2 | Glucosamine-6-phosphate deaminase 2 |
IDH1 | Isocitrate dehydrogenase 1 (NADP+), soluble |
NQO1 | NAD(P)H dehydrogenase, quinone 1 |
PTGIS | Prostaglandin I2 (prostacyclin) synthase |
SMPDL3A | Sphingomyelin phosphodiesterase, acid-like 3A |
SPPL2A | Putative intramembrane cleaving protease |
STS | Steroid sulfatase (microsomal), arylsulfatase C, isozyme S |
UBE2G1 | Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans), tv-1 |
UCHL1 | Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
Tumour Suppression | Â |
MADH3 | MAD, mothers against decapentaplegic homolog 3 (Drosophila) |
Signalling | Â |
DEPDC6 | DEP domain containing 6 |
DIRAS1 | DIRAS family, GTP-binding RAS-like 1 |
PDGFRA | Platelet-derived growth factor receptor, alpha polypeptide |
PENK | Proenkephalin |
SARA2 | SAR1a gene homolog 2 (S. cerevisiae) |
SNTB1 | Syntrophin, beta 1 (dystrophin-associated protein A1, 59 kDa, basic component 1) |
DKFZp564I1922 | Adlican |
mRNA Processing | Â |
CSTF1 | Cleavage stimulation factor, 3' pre-RNA, subunit 1, 50 kDa |
Cell Adhesion | Â |
CNTNAP1 | Contactin-associated protein 1 |
THBS2 | Thrombospondin 2 |
ZYX | Zyxin |
Apoptosis | Â |
C20orf97 | Chromosome 20 open reading frame 97 |
DAPK1 | Death-associated protein kinase 1 |
MAPK1 | Mitogen-activated protein kinase 1, tv-1 |
Structural | Â |
KRT18 | Keratin 18, tv-1 |
TUBG1 | Tubulin, gamma 1 |
Immune Response | Â |
ANKRD15 | Ankyrin repeat domain 15, tv-1 |
DPP4 | Dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) |
MR1 | Major histocompatibility complex, class I-related |
Other | Â |
ANGPTL2 | Angiopoietin-like 2 |
ANTXR2 | Anthrax toxin receptor 2 |
BCKDHB | Branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease), nuclear gene |
| Â | encoding mitochondrial protein, tv-2 |
BZRP | Benzodiazapine receptor (peripheral), tv-PBR-S |
C11orf17 | Chromosome 11 open reading frame 17, tv-2 |
C6orf32 | Chromosome 6 open reading frame 32 |
C9orf88 | Chromosome 9 open reading frame 88 |
CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 |
CRLF1 | Cytokine receptor-like factor 1 |
DIRC2 | Disrupted in renal carcinoma 2 |
EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 |
FLJ20073 | FLJ20073 protein |
FLJ20272 | Hypothetical protein FLJ20272 |
FLJ22582 | Hypothetical protein FLJ22582 |
HOM-TES-103 | HOM-TES-103 tumour antigen-like, tv-3 |
HSPC157 | HSPC157 protein |
KIAA0196 | KIAA0196 gene product |
LOC196463 | Hypothetical protein LOC196463 |
LOC221091 | Similar to hypothetical protein |
LOC286343 | Hypothetical protein LOC286343 |
LOC387908 | Similar to Ferritin heavy chain (Ferritin H subunit) |
LOC57168 | Similar to aspartate beta hydroxylase (ASPH) |
LRRFIP2 | Leucine rich repeat (in FLII) interacting protein 2 |
LYPLA1 | Lysophospholipase I |
MGC12992 | Hypothetical protein MGC12992 |
MGST1 | Microsomal glutathione S-transferase 1, tv-1a |
MOCOS | Molybdenum cofactor sulfurase |
NNT | Nicotinamide nucleotide transhydrogenase |
PKM2 | Pyruvate kinase, muscle, tv-1 |
PPAP2B | Phosphatidic acid phosphatase type 2B, tv-2 |
PSFL | Anterior pharynx defective 1B-like |
PTX3 | Pentaxin-related gene, rapidly induced by IL-1 beta |
S100A4 | S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog), tv-2 |
SLIT3 | Slit homolog 3 (Drosophila) |
SMP1 | Small membrane protein 1 |
TRIM4 | Tripartite motif-containing 4, tv-β |
UNQ564 | UNQ564 |
ZC3HAV1 | Zinc finger CCCH type, antiviral 1, tv-2 |