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Table 6 Genes commonly down-regulated 2-fold or more in desmoid tumours compared to normal fibroblast cells

From: Gene Expression Profiling in Familial Adenomatous Polyposis Adenomas and Desmoid Disease

Symbol Gene Name
Cell Cycle  
GRN Granulin
QSCN6 Quiescin Q6
STAT1 Signal transducer and activator of transcription 1,91 kDa, tv-α
STAT1 Signal transducer and activator of transcription 1,91 kDa, tv-β
TIMP1 Tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
Transcription/Transcriptional Regulation
HIST1H2BK Histone 1, H2bk
LOXL1 Lysyl oxidase-like 1
MSC Musculin (activated B-cell factor-1)
PRRX1 Paired related homeobox 1, tv-pmx-1b
ZDHHC14 Zinc finger, DHHC domain containing 14
Transport  
GLRB Glycine receptor, beta
PCOLCE2 Procollagen C-endopeptidase enhancer 2
SCAMP3 Secretory carrier membrane protein 3, tv-1
SLC31A2 Solute carrier family 31 (copper transporters), member 2
Metabolism  
AK1 Adenylate kinase 1
AKR1C3 Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
C1RL Complement component 1, r subcomponent-like
COMT Catechol-O-methyltransferase, tv-MB-COMT
CTSL Cathepsin L, tv-2
GCLM Glutamate-cysteine ligase, modifier subunit
GNPDA2 Glucosamine-6-phosphate deaminase 2
IDH1 Isocitrate dehydrogenase 1 (NADP+), soluble
NQO1 NAD(P)H dehydrogenase, quinone 1
PTGIS Prostaglandin I2 (prostacyclin) synthase
SMPDL3A Sphingomyelin phosphodiesterase, acid-like 3A
SPPL2A Putative intramembrane cleaving protease
STS Steroid sulfatase (microsomal), arylsulfatase C, isozyme S
UBE2G1 Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans), tv-1
UCHL1 Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Tumour Suppression  
MADH3 MAD, mothers against decapentaplegic homolog 3 (Drosophila)
Signalling  
DEPDC6 DEP domain containing 6
DIRAS1 DIRAS family, GTP-binding RAS-like 1
PDGFRA Platelet-derived growth factor receptor, alpha polypeptide
PENK Proenkephalin
SARA2 SAR1a gene homolog 2 (S. cerevisiae)
SNTB1 Syntrophin, beta 1 (dystrophin-associated protein A1, 59 kDa, basic component 1)
DKFZp564I1922 Adlican
mRNA Processing  
CSTF1 Cleavage stimulation factor, 3' pre-RNA, subunit 1, 50 kDa
Cell Adhesion  
CNTNAP1 Contactin-associated protein 1
THBS2 Thrombospondin 2
ZYX Zyxin
Apoptosis  
C20orf97 Chromosome 20 open reading frame 97
DAPK1 Death-associated protein kinase 1
MAPK1 Mitogen-activated protein kinase 1, tv-1
Structural  
KRT18 Keratin 18, tv-1
TUBG1 Tubulin, gamma 1
Immune Response  
ANKRD15 Ankyrin repeat domain 15, tv-1
DPP4 Dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2)
MR1 Major histocompatibility complex, class I-related
Other  
ANGPTL2 Angiopoietin-like 2
ANTXR2 Anthrax toxin receptor 2
BCKDHB Branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease), nuclear gene
  encoding mitochondrial protein, tv-2
BZRP Benzodiazapine receptor (peripheral), tv-PBR-S
C11orf17 Chromosome 11 open reading frame 17, tv-2
C6orf32 Chromosome 6 open reading frame 32
C9orf88 Chromosome 9 open reading frame 88
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CRLF1 Cytokine receptor-like factor 1
DIRC2 Disrupted in renal carcinoma 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FLJ20073 FLJ20073 protein
FLJ20272 Hypothetical protein FLJ20272
FLJ22582 Hypothetical protein FLJ22582
HOM-TES-103 HOM-TES-103 tumour antigen-like, tv-3
HSPC157 HSPC157 protein
KIAA0196 KIAA0196 gene product
LOC196463 Hypothetical protein LOC196463
LOC221091 Similar to hypothetical protein
LOC286343 Hypothetical protein LOC286343
LOC387908 Similar to Ferritin heavy chain (Ferritin H subunit)
LOC57168 Similar to aspartate beta hydroxylase (ASPH)
LRRFIP2 Leucine rich repeat (in FLII) interacting protein 2
LYPLA1 Lysophospholipase I
MGC12992 Hypothetical protein MGC12992
MGST1 Microsomal glutathione S-transferase 1, tv-1a
MOCOS Molybdenum cofactor sulfurase
NNT Nicotinamide nucleotide transhydrogenase
PKM2 Pyruvate kinase, muscle, tv-1
PPAP2B Phosphatidic acid phosphatase type 2B, tv-2
PSFL Anterior pharynx defective 1B-like
PTX3 Pentaxin-related gene, rapidly induced by IL-1 beta
S100A4 S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog), tv-2
SLIT3 Slit homolog 3 (Drosophila)
SMP1 Small membrane protein 1
TRIM4 Tripartite motif-containing 4, tv-β
UNQ564 UNQ564
ZC3HAV1 Zinc finger CCCH type, antiviral 1, tv-2