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Table 5 Genes commonly up-regulated 2-fold or more in desmoid tumours compared to normal fibroblast cells

From: Gene Expression Profiling in Familial Adenomatous Polyposis Adenomas and Desmoid Disease

Symbol Gene Name
Cell Cycle Control  
PTN Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
GAS7 Growth arrest-specific 7, tv-b
CDKN1C Cyclin-dependent kinase inhibitor 1C (p57, Kip2)
TGFB3 Transforming growth factor, beta 3
Cell Cycle  
NEK3 NIMA (never in mitosis gene a)-related kinase 3, tv-2
Transcription/Transcriptional Regulation
BHLHB2 Basic helix-loop-helix domain containing, class B, 2
COL4A1 Collagen, type IV, alpha 1
COL4A2 Collagen, type IV, alpha 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ELF2 E74-like factor 2 (ets domain transcription factor), tv-1
EVI1 Ecotropic viral integration site 1
FKBP1A FK506 binding protein 1A, 12 kDa, tv-12A
FLJ10404 Hypothetical protein FLJ10404
HDAC8 Histone deacetylase 8
JUN v-jun sarcoma virus 17 oncogene homolog (avian)
KIF2C Kinesin family member C2
NUCKS Nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate
PBX2 Pre-B-cell leukemia transcription factor 2
PPIE Peptidylprolyl isomerase E (cyclophilin E), tv-2
PRR3 Proline-rich polypeptide 3
TEAD2 TEA domain family member 2
TLE2 Transducin-like enhancer of split 2 (E(sp1)) homolog, Drosophila
TLE4 Transducin-like enhancer of split 4 (E(sp1)) homolog, Drosophila
ZNF22 Zinc finger protein 22 (KOX15)
ZNF254 Zinc finger protein 254
TDRD3 Tudor domain containing 3
ZNF300 Zinc finger protein 300
MEF2C MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
Hes4 bHLH factor Hes4
C19orf13 Chromosome 19 open reading frame 13
ARNT Aryl hydrocarbon receptor nuclear translocator, tv-2
ZNF266 Zinc finger protein 266
ZNF26 Zinc finger protein 26 (KOX 20)
MGC51082 Hypothetical protein MGC51082
TGIF2 TGFB-induced factor 2 (TALE family homeobox)
MYST3 MYST histone acetyltransferase (monocytic leukemia) 3
M96 Likely ortholog of mouse metal response element binding transcription factor 2
BAZ2B Bromodomain adjacent to zinc finger domain, 2B
Transport  
NXT1 NTF2-like export factor 1
ABCA1 ATP-binding cassette, sub-family A, member 1
SLC25A29 Solute carrier family 25, member 29
SLC16A9 Solute carrier family 16 (monocarboxylic acid transporters), member 9
PSCD1 Pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1), tv-2
AQP1 Aquaporin 1(Channel-forming integral protein, 28 kDa) tv-1
SCNN1D Sodium channel, nonvoltage-gated, delta
SLC22A17 Solute carrier family 22 (organic cation transporter), member 17, tv-2
Metabolism  
SULT1A1 Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1, tv-1
CH25H Cholesterol 25-hydroxylase
QTRTD1 Queuine tRNA-ribosyltransferase domain containing 1
FLJ23749 Hypothetical protein FLJ23749
FLJ10706 Hypothetical protein FLJ10706
USP52 Ubiquitin specific protease 52
RARRES2 Retinoic acid receptor responder (tazarotene induced) 2
ADAM19 A distintegrin and metalloproteinase domain 19 (meltrin beta), tv-2
AUTS2 Autism susceptibility candidate 2
GALNT3 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
KIAA0140 KIAA0140
ODC-p Ornithine decarboxylase-like
PCSK5 Proprotein convertase subtilisin/kexin type 5
Oncogenesis  
AKAP13 A kinase (PRKA) anchor protein 13, tv-3
MGP Matrix Gla protein
EWSR1 Ewing sarcoma breakpoint region 1, tv-EWS-b
SFRP4 Secreted frizzled-related protein 4
SRPUL Sushi-repeat protein
Signalling  
GABBR1 Gamma-aminobutyric acid (GABA) B receptor, 1, tv-2
CAPS Calcyphosine, tv-2
NET1 Neuroepithelial cell transforming gene 1
PRKCH Protein kinase C, eta
PPP2R2B Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), beta isoform, tv-4
RGS16 Regulator of G-protein signalling 16
PTHR1 Parathyroid hormone receptor 1
TMPEI Transmembrane, prostate androgen induced RNA, tv-4
ARHU Ras homolog gene family, member U
CHN1 Chimerin (chimaerin) 1
EFNB3 Ephrin-B3
GFRA2 GDNF family receptor alpha 2
GNB4 Guanine nucleotide binding protein (G protein), beta polypeptide 4
IL11RA Interleukin 11 receptor, alpha, tv-1
ITPKB Inositol 1,4,5-trisphosphate 3-kinase B
KIF13B Kinesin family member 13B
MAP4K1 Mitogen-activated protein kinase kinase kinase kinase 1
MLP MARCKS-like protein
PDGFRL Platelet-derived growth factor receptor-like
PRKCABP Protein kinase C, alpha binding protein
RASD1 RAS, dexamethasone-induced 1
TNFAIP6 Tumour necrosis factor, alpha-induced protein 6
Cell Adhesion  
COL7A1 Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)
ISLR Immunoglobulin superfamily containing leucine-rich repeat, tv-1
Apoptosis  
PPP1R13B Protein phosphatase 1, regulatory (inhibitor) subunit 13B
AXUD1 AXIN1 up-regulated 1
CASP10 Caspase 10, apoptosis-related cysteine protease, tv-B
MX1 Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
PCBP4 Poly(rC) binding protein 4, tv-4
TNFRSF19 Tumour necrosis factor receptor superfamily, member 19, tv-2
TNFRSF25 Tumour necrosis factor receptor superfamily, member 25, tv-7
Tumourigenesis  
BARD1 BRCA1 associated RING domain 1
LOH11CR2A Loss of heterozygosity, 11, chromosomal region 2, gene A
Immune Response  
HLA-DPA1 Major histocompatibility complex, class II, DP alpha 1
C1R Complement component 1, r subcomponent
CXCL14 Chemokine (C-X-C motif) ligand 14
IFI27 Interferon, alpha-inducible protein 27, tv-α
MX2 Myxovirus (influenza virus) resistance 2 (mouse)
RNA Processing  
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
HNRPA1 Heterogeneous nuclear ribonucleoprotein A1, tv-1
SFRS11 Splicing factor, arginine/serine-rich 11
Structural  
ACTL6 Actin-like 6
FBLN1 Fibulin 1 (FBLN1), tv-C
FBLN1 Fibulin 1 (FBLN1), tv-D
SMTN Smoothelin, tv-2
Other  
MT1H Metallothionein 1H
C12orf14 Chromosome 12 open reading frame 14
PELI1 Pellino homolog 1 (Drosophila)
IFI44 Interferon-induced protein 44
C10orf6 Chromosome 10 open reading frame 6
C2orf11 Chromosome 2 open reading frame 11
FLJ31951 Hypothetical protein FLJ31951
ISYNA1 Myo-inositol 1-phosphate synthase A1
FLJ31614 Hypothetical protein FLJ31614
AD031 AD031 protein
CASC3 Cancer susceptibility candidate 3
GBA2 Glucosidase, beta (bile acid) 2
CGI-85 CGI-85 protein, tv-2
C14orf80 Chromosome 14 open reading frame 80
ACAS2L Acetyl-Coenzyme A synthetase 2 (AMP forming)-like, nuclear gene encoding mitochondrial protein
DTX3 Deltex 3 homolog (Drosophila)
FLJ23059 Hypothetical protein FLJ23059
PIK3R1 Phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha), tv-2
KIAA1223 KIAA1223
STARD9 START domain containing 9
LOC375786 Hypothetical gene supported by AL713796
SR140 U2-associated SR140 protein
MIDN Midnolin
SEC31L2 SEC31-like 2 (S. cerevisiae), tv-1
FLJ12178 Hypothetical protein FLJ12178
LOC157567 Hypothetical protein LOC157567
FLJ25005 FLJ25005 protein
WARP von Willebrand factor A domain-related protein, tv-1
KIAA1036 KIAA1036
LOC374969 Hypothetical protein LOC374969
LOC155435 Hypothetical protein LOC155435
MGC9913 Hypothetical protein MGC9913
CASKIN2 CASK interacting protein 2
CFDP1 Craniofacial development protein 1
SPAG5 Sperm associated antigen 5
MMP23B Matrix metalloproteinase 23B
AKAP8L A kinase (PRKA) anchor protein 8-like
FLJ11029 Hypothetical protein FLJ11029
DDIT4 DNA-damage-inducible tv-4
APCDD1 Adenomatous Polyposis Coli down-regulated 1
CDW92 CDW92 antigen