Table 5 Genes commonly up-regulated 2-fold or more in desmoid tumours compared to normal fibroblast cells
From: Gene Expression Profiling in Familial Adenomatous Polyposis Adenomas and Desmoid Disease
Symbol | Gene Name |
|---|---|
Cell Cycle Control | Â |
PTN | Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) |
GAS7 | Growth arrest-specific 7, tv-b |
CDKN1C | Cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
TGFB3 | Transforming growth factor, beta 3 |
Cell Cycle | Â |
NEK3 | NIMA (never in mitosis gene a)-related kinase 3, tv-2 |
Transcription/Transcriptional Regulation | |
BHLHB2 | Basic helix-loop-helix domain containing, class B, 2 |
COL4A1 | Collagen, type IV, alpha 1 |
COL4A2 | Collagen, type IV, alpha 2 |
DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
ELF2 | E74-like factor 2 (ets domain transcription factor), tv-1 |
EVI1 | Ecotropic viral integration site 1 |
FKBP1A | FK506 binding protein 1A, 12 kDa, tv-12A |
FLJ10404 | Hypothetical protein FLJ10404 |
HDAC8 | Histone deacetylase 8 |
JUN | v-jun sarcoma virus 17 oncogene homolog (avian) |
KIF2C | Kinesin family member C2 |
NUCKS | Nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate |
PBX2 | Pre-B-cell leukemia transcription factor 2 |
PPIE | Peptidylprolyl isomerase E (cyclophilin E), tv-2 |
PRR3 | Proline-rich polypeptide 3 |
TEAD2 | TEA domain family member 2 |
TLE2 | Transducin-like enhancer of split 2 (E(sp1)) homolog, Drosophila |
TLE4 | Transducin-like enhancer of split 4 (E(sp1)) homolog, Drosophila |
ZNF22 | Zinc finger protein 22 (KOX15) |
ZNF254 | Zinc finger protein 254 |
TDRD3 | Tudor domain containing 3 |
ZNF300 | Zinc finger protein 300 |
MEF2C | MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) |
NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) |
Hes4 | bHLH factor Hes4 |
C19orf13 | Chromosome 19 open reading frame 13 |
ARNT | Aryl hydrocarbon receptor nuclear translocator, tv-2 |
ZNF266 | Zinc finger protein 266 |
ZNF26 | Zinc finger protein 26 (KOX 20) |
MGC51082 | Hypothetical protein MGC51082 |
TGIF2 | TGFB-induced factor 2 (TALE family homeobox) |
MYST3 | MYST histone acetyltransferase (monocytic leukemia) 3 |
M96 | Likely ortholog of mouse metal response element binding transcription factor 2 |
BAZ2B | Bromodomain adjacent to zinc finger domain, 2B |
Transport | Â |
NXT1 | NTF2-like export factor 1 |
ABCA1 | ATP-binding cassette, sub-family A, member 1 |
SLC25A29 | Solute carrier family 25, member 29 |
SLC16A9 | Solute carrier family 16 (monocarboxylic acid transporters), member 9 |
PSCD1 | Pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1), tv-2 |
AQP1 | Aquaporin 1(Channel-forming integral protein, 28 kDa) tv-1 |
SCNN1D | Sodium channel, nonvoltage-gated, delta |
SLC22A17 | Solute carrier family 22 (organic cation transporter), member 17, tv-2 |
Metabolism | Â |
SULT1A1 | Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1, tv-1 |
CH25H | Cholesterol 25-hydroxylase |
QTRTD1 | Queuine tRNA-ribosyltransferase domain containing 1 |
FLJ23749 | Hypothetical protein FLJ23749 |
FLJ10706 | Hypothetical protein FLJ10706 |
USP52 | Ubiquitin specific protease 52 |
RARRES2 | Retinoic acid receptor responder (tazarotene induced) 2 |
ADAM19 | A distintegrin and metalloproteinase domain 19 (meltrin beta), tv-2 |
AUTS2 | Autism susceptibility candidate 2 |
GALNT3 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) |
KIAA0140 | KIAA0140 |
ODC-p | Ornithine decarboxylase-like |
PCSK5 | Proprotein convertase subtilisin/kexin type 5 |
Oncogenesis | Â |
AKAP13 | A kinase (PRKA) anchor protein 13, tv-3 |
MGP | Matrix Gla protein |
EWSR1 | Ewing sarcoma breakpoint region 1, tv-EWS-b |
SFRP4 | Secreted frizzled-related protein 4 |
SRPUL | Sushi-repeat protein |
Signalling | Â |
GABBR1 | Gamma-aminobutyric acid (GABA) B receptor, 1, tv-2 |
CAPS | Calcyphosine, tv-2 |
NET1 | Neuroepithelial cell transforming gene 1 |
PRKCH | Protein kinase C, eta |
PPP2R2B | Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), beta isoform, tv-4 |
RGS16 | Regulator of G-protein signalling 16 |
PTHR1 | Parathyroid hormone receptor 1 |
TMPEI | Transmembrane, prostate androgen induced RNA, tv-4 |
ARHU | Ras homolog gene family, member U |
CHN1 | Chimerin (chimaerin) 1 |
EFNB3 | Ephrin-B3 |
GFRA2 | GDNF family receptor alpha 2 |
GNB4 | Guanine nucleotide binding protein (G protein), beta polypeptide 4 |
IL11RA | Interleukin 11 receptor, alpha, tv-1 |
ITPKB | Inositol 1,4,5-trisphosphate 3-kinase B |
KIF13B | Kinesin family member 13B |
MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1 |
MLP | MARCKS-like protein |
PDGFRL | Platelet-derived growth factor receptor-like |
PRKCABP | Protein kinase C, alpha binding protein |
RASD1 | RAS, dexamethasone-induced 1 |
TNFAIP6 | Tumour necrosis factor, alpha-induced protein 6 |
Cell Adhesion | Â |
COL7A1 | Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) |
ISLR | Immunoglobulin superfamily containing leucine-rich repeat, tv-1 |
Apoptosis | Â |
PPP1R13B | Protein phosphatase 1, regulatory (inhibitor) subunit 13B |
AXUD1 | AXIN1 up-regulated 1 |
CASP10 | Caspase 10, apoptosis-related cysteine protease, tv-B |
MX1 | Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
PCBP4 | Poly(rC) binding protein 4, tv-4 |
TNFRSF19 | Tumour necrosis factor receptor superfamily, member 19, tv-2 |
TNFRSF25 | Tumour necrosis factor receptor superfamily, member 25, tv-7 |
Tumourigenesis | Â |
BARD1 | BRCA1 associated RING domain 1 |
LOH11CR2A | Loss of heterozygosity, 11, chromosomal region 2, gene A |
Immune Response | Â |
HLA-DPA1 | Major histocompatibility complex, class II, DP alpha 1 |
C1R | Complement component 1, r subcomponent |
CXCL14 | Chemokine (C-X-C motif) ligand 14 |
IFI27 | Interferon, alpha-inducible protein 27, tv-α |
MX2 | Myxovirus (influenza virus) resistance 2 (mouse) |
RNA Processing | Â |
DHX8 | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
HNRPA1 | Heterogeneous nuclear ribonucleoprotein A1, tv-1 |
SFRS11 | Splicing factor, arginine/serine-rich 11 |
Structural | Â |
ACTL6 | Actin-like 6 |
FBLN1 | Fibulin 1 (FBLN1), tv-C |
FBLN1 | Fibulin 1 (FBLN1), tv-D |
SMTN | Smoothelin, tv-2 |
Other | Â |
MT1H | Metallothionein 1H |
C12orf14 | Chromosome 12 open reading frame 14 |
PELI1 | Pellino homolog 1 (Drosophila) |
IFI44 | Interferon-induced protein 44 |
C10orf6 | Chromosome 10 open reading frame 6 |
C2orf11 | Chromosome 2 open reading frame 11 |
FLJ31951 | Hypothetical protein FLJ31951 |
ISYNA1 | Myo-inositol 1-phosphate synthase A1 |
FLJ31614 | Hypothetical protein FLJ31614 |
AD031 | AD031 protein |
CASC3 | Cancer susceptibility candidate 3 |
GBA2 | Glucosidase, beta (bile acid) 2 |
CGI-85 | CGI-85 protein, tv-2 |
C14orf80 | Chromosome 14 open reading frame 80 |
ACAS2L | Acetyl-Coenzyme A synthetase 2 (AMP forming)-like, nuclear gene encoding mitochondrial protein |
DTX3 | Deltex 3 homolog (Drosophila) |
FLJ23059 | Hypothetical protein FLJ23059 |
PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha), tv-2 |
KIAA1223 | KIAA1223 |
STARD9 | START domain containing 9 |
LOC375786 | Hypothetical gene supported by AL713796 |
SR140 | U2-associated SR140 protein |
MIDN | Midnolin |
SEC31L2 | SEC31-like 2 (S. cerevisiae), tv-1 |
FLJ12178 | Hypothetical protein FLJ12178 |
LOC157567 | Hypothetical protein LOC157567 |
FLJ25005 | FLJ25005 protein |
WARP | von Willebrand factor A domain-related protein, tv-1 |
KIAA1036 | KIAA1036 |
LOC374969 | Hypothetical protein LOC374969 |
LOC155435 | Hypothetical protein LOC155435 |
MGC9913 | Hypothetical protein MGC9913 |
CASKIN2 | CASK interacting protein 2 |
CFDP1 | Craniofacial development protein 1 |
SPAG5 | Sperm associated antigen 5 |
MMP23B | Matrix metalloproteinase 23B |
AKAP8L | A kinase (PRKA) anchor protein 8-like |
FLJ11029 | Hypothetical protein FLJ11029 |
DDIT4 | DNA-damage-inducible tv-4 |
APCDD1 | Adenomatous Polyposis Coli down-regulated 1 |
CDW92 | CDW92 antigen |