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Table 4 Genes commonly down-regulated 2-fold or more in colorectal FAP polyps compared to normal colon

From: Gene Expression Profiling in Familial Adenomatous Polyposis Adenomas and Desmoid Disease

Symbol

Gene Name

Cell Cycle Control

 

FOSB

FBJ murine osteosarcoma viral oncogene homolog B

PPP3CB

Protein phosphatase 3, catalytic subunit, beta isoform (calcineurn A beta)

Cell Cycle

 

MXI1

MAX interacting protein 1, tv-2

CABLES1

Cdk5 and Abl enzyme substrate 1

PMP22

Peripheral myelin protein 22, tv-3

DTR

Diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)

Transcription/Transcriptional Regulation

HLX1

H2.0-like homeo box 1 (Drosophila)

NKX2–3

NK2 transcription factor related, locus 3 (Drosophila)

SOX18

SRY (sex determining region Y)-box 18

FNBP1

Formin-binding protein 1

COL4A1

Collagen, type IV, alpha 1

SIRT6

Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)

SIRT7

Sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)

AIM1L

Absent in melanoma 1-like

C19orf21

Chromosome 19 open reading frame 21

Transport

 

FBXO32

F-box only protein 32, tv-2

KCNMA1

Potassium large conductance calcium-activated channel, subfamily M, alpha member 1

MYADM

Myeloid-associated differentiation marker

AQP8

Aquaporin 8

SLC17A4

Solute carrier family 17 (sodium phosphate), member 4

SLCO2A1

Solute carrier organic anion transporter family, member 2A1

SGK

Serum/glucocorticoid regulated kinase

P2RX4

Purinergic receptor P2X, ligand-gated ion channel, 4, tv-2

SLC20A1

Solute carrier family 20 (phosphate transporter), member 1

VAMP5

Vesicle-associated membrane protein 5 (myobrevin)

Metabolism

 

MGC4171

Hypothetical protein MGC4171

LIPH

Lipase, member H

KIAA0992

Palladin

KIAA0828

KIAA0828 protein

SULT1A2

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2, tv-1

UPP1

Uridine phosphorylase 1, tv-1

BTNL3

Butyrophilin-like 3, tv-2

KIAA0934

KIAA0934 protein

AK1

Adenylate kinase 1

DPYSL3

Dihydropyrimidinase-like 3

PLCD1

Phospholipase C, delta 1

CA4

Carbonic anhydrase IV

SVIL

Supervillin, tv-1

PC

Pyruvate carboxylase, nuclear gene encoding mitochondrial protein, tv-2

TMPRSS2

Transmembrane protease, serine 2

PRSS3

Protease, serine, 3 (mesotrypsin)

PCK1

Phosphoenolpyruvate carboxykinase 1 (soluble)

ST6GALNAC6

CMP-NeuAC: (beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member IV

RARRES2

Retinoic acid receptor responder (tazarotene induced) 2

Tumour Suppression

 

PPAP2A

Phosphatidic acid phosphatase type 2A, tv-1

Signalling

 

RGL1

Ral guanine nucleotide dissociation stimulator-like 1

EFNA1

Ephrin-A1, tv-1

SDCBP2

Syndecan binding protein (syntenin) 2, tv-2

GUCA2A

Guanylate cyclase activator 2A (guanylin)

BSG

Basigin (OK blood group), tv-4

TRIF

TIR domain containing adaptor inducing interferon-beta

ILK

Integrin-linked kinase

TJP3

Tight junction protein 3 (zona occludens 3)

PRKCD

Protein kinase C, delta

ITPKA

Inositol 1,4,5-trisposphate 3-kinase A

IL2RG

Interleukin 2 receptor, gamma (severe combined immunodeficiency)

LNK

Lymphocyte adaptor protein

Cell Adhesion

 

PC-LKC

Protocadherin LKC

DCN

Decorin, tv-E

FLNA

Filamin A, alpha (actin binding protein 280)

MSN

Moesin

SORBS1

Sorbin and SH3 domain containing 1

TAGLN

Transgelin

CDC42

Cell division cycle 42 (GTP binding protein, 25 kDa), tv-2

COL4A2

Collagen, type IV, alpha 2

DBN1

Drebin 1, tv-1

GSN

Gelsolin (amyloidosis, Finnish type), tv-2

ACTG2

Actin, gamma 2, smooth muscle, enteric

ACTA2

Actin, alpha 2, smooth muscle, aorta

CGN

Cingulin

Apoptosis

 

RIPK3

Receptor-interacting serine-threonine kinase 3

FOSL2

FOS-like antigen 2

DAPK3

Death-associated protein kinase 3

LGALS1

Lectin, galactoside-binding, soluble, 1 (galactin 1)

GADD45B

Growth arrest and DNA-damage-inducible, beta

Structural

 

CLDN5

Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)

KRT19

Keratin 19

TPM2

Tropomyosin 2 (beta)

Other

 

DUSP5

Dual specificity phosphatase 5

CLIPR-59

CLIP-170-related protein

PTPRR

Protein tyrosine phosphatase, receptor type, R, tv-2

SMTN

Smoothelin, tv-2

CEACAM1

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

EPS8L2

EPS8-like 2

RICH1

RhoGAP interacting with CIP4 homologs 1

PDZK2

PDZ domain containing 2

CHKL

Choline kinase-like, tv-1

DIP13B

DIP13 beta

NS5ATP13TP2

NS5ATP13TP2 protein

M-RIP

Myosin phosphatase-Rho interacting protein

MTMR9

Myotubularin related protein 9

LRRC1

Leucine rich repeat containing 1

CTGF

Connective tissue growth factor

DSCR1L1

Down syndrome critical region gene 1-like 1

TU12B1-TY

TU12B1-TY protein

MYH11

Myosin, heavy polypeptide 11, smooth muscle, tv-SM1

FLJ23471

MICAL-like 2, tv-2

DKFZP434B044

Hypothetical protein DKFZp434B044

MUCDHL

Mucin and cadherin-like, tv-2

MMP28

Matrix metalloproteinase 28, tv-1

TRIM15

Tripartite motif-containing 15, tv-1

COL6A2

Collagen, type VI, alpha 2, tv-2C2

SELM

Selenoprotein SelM

ZAK

Sterile alpha motif and leucine zipper containing kinase AZK

SMTN

Smoothelin, tv-3

TNXB

Tenascin XB, tv-XB-S

EPS8L1

EPS8-like 1, tv-3

FLJ10350

Hypothetical protein FLJ10350

DKFZP762C186

Tangerin

TBC1D1

TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1

KIAA1145

KIAA1145 protein

PKIG

Protein kinase (cAMP-dependent, catalytic) inhibitor gamma, tv-2

PKIB

Protein kinase (cAMP-dependent, catalytic) inhibitor beta, tv-3

IGSF9

Immunoglobulin superfamily, member 9

LOC90313

Hypothetical protein BC004507

FLJ22582

Hypothetical protein FLJ22582

KIAA0063

KIAA0063 gene product

FSTL1

Follistatin-like 1

PRNP

Prion protein (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia), tv-2

ANKRD25

Ankyrin repeat domain 25

STOM

Stomatin, tv-2

FLJ46603

FLJ46603 protein

RAIN

Ras-interacting protein

DHRS9

Dehydrogenase/reductase (SDR family) member 9, tv-1

LIMS2

LIM and senescent cell antigen-like domains 2

ARHGEF18

Rho/rac guanine nucleotide exchange factor (GEF) 18

KIAA0285

KIAA0285 gene product

PDLIM7

PDZ and LIM domain 7 (enigma), tv-1

CXX1

CAAX box 1

MGP

Matrix GIa protein

PTPRH

Protein tyrosine phosphatase, receptor type, H

SPARC

Secreted protein, acidic, cysteine-rich (osteonectin)

FLJ90022

Hypothetical protein FLJ90022

SERPING1

Serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)

CSRP1

Cysteine and glycine-rich protein 1

KIAA0513

KIAA0513 gene product

OAS1

2',5'-oligoadenylate synthetase 1, 40/46 kDa