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Table 4 Genes commonly down-regulated 2-fold or more in colorectal FAP polyps compared to normal colon

From: Gene Expression Profiling in Familial Adenomatous Polyposis Adenomas and Desmoid Disease

Symbol Gene Name
Cell Cycle Control  
FOSB FBJ murine osteosarcoma viral oncogene homolog B
PPP3CB Protein phosphatase 3, catalytic subunit, beta isoform (calcineurn A beta)
Cell Cycle  
MXI1 MAX interacting protein 1, tv-2
CABLES1 Cdk5 and Abl enzyme substrate 1
PMP22 Peripheral myelin protein 22, tv-3
DTR Diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)
Transcription/Transcriptional Regulation
HLX1 H2.0-like homeo box 1 (Drosophila)
NKX2–3 NK2 transcription factor related, locus 3 (Drosophila)
SOX18 SRY (sex determining region Y)-box 18
FNBP1 Formin-binding protein 1
COL4A1 Collagen, type IV, alpha 1
SIRT6 Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
SIRT7 Sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
AIM1L Absent in melanoma 1-like
C19orf21 Chromosome 19 open reading frame 21
Transport  
FBXO32 F-box only protein 32, tv-2
KCNMA1 Potassium large conductance calcium-activated channel, subfamily M, alpha member 1
MYADM Myeloid-associated differentiation marker
AQP8 Aquaporin 8
SLC17A4 Solute carrier family 17 (sodium phosphate), member 4
SLCO2A1 Solute carrier organic anion transporter family, member 2A1
SGK Serum/glucocorticoid regulated kinase
P2RX4 Purinergic receptor P2X, ligand-gated ion channel, 4, tv-2
SLC20A1 Solute carrier family 20 (phosphate transporter), member 1
VAMP5 Vesicle-associated membrane protein 5 (myobrevin)
Metabolism  
MGC4171 Hypothetical protein MGC4171
LIPH Lipase, member H
KIAA0992 Palladin
KIAA0828 KIAA0828 protein
SULT1A2 Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2, tv-1
UPP1 Uridine phosphorylase 1, tv-1
BTNL3 Butyrophilin-like 3, tv-2
KIAA0934 KIAA0934 protein
AK1 Adenylate kinase 1
DPYSL3 Dihydropyrimidinase-like 3
PLCD1 Phospholipase C, delta 1
CA4 Carbonic anhydrase IV
SVIL Supervillin, tv-1
PC Pyruvate carboxylase, nuclear gene encoding mitochondrial protein, tv-2
TMPRSS2 Transmembrane protease, serine 2
PRSS3 Protease, serine, 3 (mesotrypsin)
PCK1 Phosphoenolpyruvate carboxykinase 1 (soluble)
ST6GALNAC6 CMP-NeuAC: (beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member IV
RARRES2 Retinoic acid receptor responder (tazarotene induced) 2
Tumour Suppression  
PPAP2A Phosphatidic acid phosphatase type 2A, tv-1
Signalling  
RGL1 Ral guanine nucleotide dissociation stimulator-like 1
EFNA1 Ephrin-A1, tv-1
SDCBP2 Syndecan binding protein (syntenin) 2, tv-2
GUCA2A Guanylate cyclase activator 2A (guanylin)
BSG Basigin (OK blood group), tv-4
TRIF TIR domain containing adaptor inducing interferon-beta
ILK Integrin-linked kinase
TJP3 Tight junction protein 3 (zona occludens 3)
PRKCD Protein kinase C, delta
ITPKA Inositol 1,4,5-trisposphate 3-kinase A
IL2RG Interleukin 2 receptor, gamma (severe combined immunodeficiency)
LNK Lymphocyte adaptor protein
Cell Adhesion  
PC-LKC Protocadherin LKC
DCN Decorin, tv-E
FLNA Filamin A, alpha (actin binding protein 280)
MSN Moesin
SORBS1 Sorbin and SH3 domain containing 1
TAGLN Transgelin
CDC42 Cell division cycle 42 (GTP binding protein, 25 kDa), tv-2
COL4A2 Collagen, type IV, alpha 2
DBN1 Drebin 1, tv-1
GSN Gelsolin (amyloidosis, Finnish type), tv-2
ACTG2 Actin, gamma 2, smooth muscle, enteric
ACTA2 Actin, alpha 2, smooth muscle, aorta
CGN Cingulin
Apoptosis  
RIPK3 Receptor-interacting serine-threonine kinase 3
FOSL2 FOS-like antigen 2
DAPK3 Death-associated protein kinase 3
LGALS1 Lectin, galactoside-binding, soluble, 1 (galactin 1)
GADD45B Growth arrest and DNA-damage-inducible, beta
Structural  
CLDN5 Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)
KRT19 Keratin 19
TPM2 Tropomyosin 2 (beta)
Other  
DUSP5 Dual specificity phosphatase 5
CLIPR-59 CLIP-170-related protein
PTPRR Protein tyrosine phosphatase, receptor type, R, tv-2
SMTN Smoothelin, tv-2
CEACAM1 Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
EPS8L2 EPS8-like 2
RICH1 RhoGAP interacting with CIP4 homologs 1
PDZK2 PDZ domain containing 2
CHKL Choline kinase-like, tv-1
DIP13B DIP13 beta
NS5ATP13TP2 NS5ATP13TP2 protein
M-RIP Myosin phosphatase-Rho interacting protein
MTMR9 Myotubularin related protein 9
LRRC1 Leucine rich repeat containing 1
CTGF Connective tissue growth factor
DSCR1L1 Down syndrome critical region gene 1-like 1
TU12B1-TY TU12B1-TY protein
MYH11 Myosin, heavy polypeptide 11, smooth muscle, tv-SM1
FLJ23471 MICAL-like 2, tv-2
DKFZP434B044 Hypothetical protein DKFZp434B044
MUCDHL Mucin and cadherin-like, tv-2
MMP28 Matrix metalloproteinase 28, tv-1
TRIM15 Tripartite motif-containing 15, tv-1
COL6A2 Collagen, type VI, alpha 2, tv-2C2
SELM Selenoprotein SelM
ZAK Sterile alpha motif and leucine zipper containing kinase AZK
SMTN Smoothelin, tv-3
TNXB Tenascin XB, tv-XB-S
EPS8L1 EPS8-like 1, tv-3
FLJ10350 Hypothetical protein FLJ10350
DKFZP762C186 Tangerin
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
KIAA1145 KIAA1145 protein
PKIG Protein kinase (cAMP-dependent, catalytic) inhibitor gamma, tv-2
PKIB Protein kinase (cAMP-dependent, catalytic) inhibitor beta, tv-3
IGSF9 Immunoglobulin superfamily, member 9
LOC90313 Hypothetical protein BC004507
FLJ22582 Hypothetical protein FLJ22582
KIAA0063 KIAA0063 gene product
FSTL1 Follistatin-like 1
PRNP Prion protein (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia), tv-2
ANKRD25 Ankyrin repeat domain 25
STOM Stomatin, tv-2
FLJ46603 FLJ46603 protein
RAIN Ras-interacting protein
DHRS9 Dehydrogenase/reductase (SDR family) member 9, tv-1
LIMS2 LIM and senescent cell antigen-like domains 2
ARHGEF18 Rho/rac guanine nucleotide exchange factor (GEF) 18
KIAA0285 KIAA0285 gene product
PDLIM7 PDZ and LIM domain 7 (enigma), tv-1
CXX1 CAAX box 1
MGP Matrix GIa protein
PTPRH Protein tyrosine phosphatase, receptor type, H
SPARC Secreted protein, acidic, cysteine-rich (osteonectin)
FLJ90022 Hypothetical protein FLJ90022
SERPING1 Serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)
CSRP1 Cysteine and glycine-rich protein 1
KIAA0513 KIAA0513 gene product
OAS1 2',5'-oligoadenylate synthetase 1, 40/46 kDa