Table 3 Genes commonly up-regulated 2-fold or more in colorectal FAP polyps compared to normal colon
From: Gene Expression Profiling in Familial Adenomatous Polyposis Adenomas and Desmoid Disease
Symbol | Gene Name |
|---|---|
Cell Cycle Control | Â |
CCNB2 | Cyclin B2 |
CDKN3 | Cyclin-dependent kinase inhibitor 3 |
AURKB | Aurora kinase B |
Cell Cycle | Â |
HCAP-G | Chromosome condensation protein G |
PRC1 | Protein regulator of cytokinesis 1, tv-1 |
KIF2C | Kinesin family member 2C |
CHC1 | Chromosome condensation 1 |
SMC4L1 | SMC4 structural maintenance of chromosome 4-like 1 (yeast) |
Pfs2 | DNA replication complex GINS protein PSF2 |
RNASEH2A | Ribonuclease H2, large subunit |
Transcription/Transcriptional Regulation | |
FLJ20315 | Hypothetical protein FLJ20315 |
TBPL1 | TBP-like 1 |
LOC89958 | Hypothetical protein LOC89958 |
HMGN1 | High-mobility group nucleosome binding domain 1 |
ZNF22 | Zinc finger protein 22 (KOX 15) |
PTTG1 | Pituitary tumour-transforming 1 |
NFE2L3 | Nuclear factor (erythroid-derived 2)-like 3 |
SOX9 | SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal) |
Transport | Â |
SLC12A2 | Solute carrier family 12 (sodium/potassium/chloride transporters) member 2 |
CLCA1 | Chloride channel, calcium activated, family member 1 |
LCN2 | Lipocalin 2 (oncogene 24p3) |
Metabolism | Â |
SORD | Sorbitol dehydrogenase |
TPRT | Trans-prenyltransferase |
QTRT1 | Queuine tRNA-ribosyltransferase 1 (tRNA-guanine transglycosylase) |
PAICS | Phosphoribosylaminoimidazole carboxylase, Phosphoribosylaminoimidazole succinocarboxamide synthetase |
DPH2L2 | DPH2-like 2 (S. cerevisiae), tv-1 |
ALOX5 | Arachidonate 5-lipoxygenase |
IARS | Isoleucine-tRNA synthetase, tv-short |
BRIX | BRIX |
TK1 | Thymidine kinase 1, soluble |
Oncogenesis | Â |
EPHB2 | EphB2 (EPHB2), tv-1 |
BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) tv-1 |
MAP17 | Membrane-associated protein 17 |
GDF15 | Growth differentiation factor 15 |
Signalling | Â |
RACGAP1 | Rac GTPase activating protein 1 |
mRNA Processing | Â |
LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
THOC3 | THO complex 3 |
Cell Adhesion | Â |
C20orf42 | Chromosome 20 open reading frame 42 |
Translation | Â |
UK114 | Translational inhibitor protein p14.5 |
Other | Â |
ZCWCC2 | Zinc finger, CW-type with coiled-coil domain 2 |
KIAA1324 | Maba1 |
FLJ10514 | Hypothetical protein FLJ10514 |
ENC1 | Ectodermal-neural cortex (with BTB-like domain) |
PTTG2 | Pituitary tumour-transforming 2 |
C21orf59 | Chromosome 21 open reading frame 59 |
WDR12 | WD repeat domain 12 |
LXN | Latexin protein |
Other | Â |
KIAA1892 | KIAA1892 |
KIAA1797 | KIAA1797 |
GLCE | Glucuronyl C5-epimerase |
KIAA0101 | KIAA0101 gene product |
RRP46 | Exosome component Rrp46 |
S100P | S100 calcium binding protein P |
PRDX4 | Peroxiredoxin 4 |
FLJ20366 | Hypothetical protein FLJ20366 |
F12 | Coagulation factor XII (Hageman factor) |
IGFBP2 | Insulin-like growth factor binding protein 2 (36 kD) |
GW112 | Differentially expressed in hematopoietic lineages |
C10orf3 | Chromosome 10 open reading frame 3 |
ATOH8 | Atonal homolog 8 (Drosophila) |
MFN1 | Mitofusin 1, nuclear gene encoding mitochondrial protein, tv-2 |
QPCT | Glutaminyl-peptide cyclotransferase (glutaminyl cyclase) |
UBE2S | Ubiquitin-conjugating enzyme E2S |