Selected aspects of genetic counselling for BRCA1 mutation carriers

Table 9 The effect of tamoxifen on the risk of contralateral breast cancer by menopausal status (univariate analysis)

Parameters	n	OR	95% CI	p
Both cancers premenopausal	86	0.31	0.11-0.82	0.02
A. All carriers:	259	0.44	0.27-0.65	0.0009
- Pre- and postmenopausal	114	0.54	0.27-1.05	0.07
- Both cancers postmenopausal	37	0.33	0.11-1.01	0.05
B. Natural menopause only:
- Pre- and postmenopausal	22	0.13	0.02-1.10	0.06
- Both cancers postmenopausal	13	0.45	0.09-2.37	0.34

CI - confidence interval; n - number of cases; OR - odds ratio; p - statistical significance.

ISSN: 1897-4287