Selected aspects of genetic counselling for BRCA1 mutation carriers

Table 6 The effect of some factors on the risk of ovarian cancer in BRCA1 mutation carriers

Parameters	Cancer patients (n = 150)	Control group (n = 150)	OR	95% CI	p
Year of birth	1951.8	1951.7			0.95
Age at diagnosis	47.5
Age at menarche	13.7	14.0	0.9^a	0.8-1.0	0.09
Parity	2.0	2.2	0.9^b	0.7-1.2	0.35
Cigarette smoking	49%	45%	1.3	0.8-2.3	0.25
Coffee consumption	73%	77%	0.7	0.4-1.3	0.21
Oophorectomy^c	2.0%	3.7%	0.4	0.1-1.1	0.08
Breast-feeding:
never	22%	19%
≤ 1 year	58%	58%	1.0	0.5-1.9	0.97
> 1 year	20%	23%	1.0	0.4-2.6	0.97
Contraceptives:
never	92%	86%
ever	8%	14%	0.4	0.2-1.0	0.04
ever ≤ 2 years	6%	4%	0.8	0.2-2.5	0.69
ever > 2 years	2%	10%	0.2	0.1-0.7	0.01

CI - confidence interval; n - number of cases; OR - odds ratio; p - statistical significance.
^a - per additional year; ^b - per additional birth; ^c - prior to diagnosis of breast cancer.

ISSN: 1897-4287