Selected aspects of genetic counselling for BRCA1 mutation carriers

Table 5 The effect of some factors on the risk of breast cancer in BRCA1 mutation carriers

Parameters	Cancer patients (n = 348)	Control group (n = 348)	OR	95% CI	p
Year of birth	1956.3	1956.7			0.58
Age at diagnosis	41.0
Age at menarche	13.5	13.8	0.9^a	0.8-1.0	0.004
Parity	2.1	2.0	1.2^b	1.0-1.4	0.02
Cigarette smoking	46%	46%	1.1	0.8-1.5	0.69
Coffee consumption	74%	78%	0.8	0.5-1.1	0.21
Oophorectomy^c	2.0%	3.7%	0.4	0.1-1.1	0.08
Breast-feeding:
never	20%	18%	1.0
≤ 1 year	58%	55%	0.8	0.5-1.3	0.37
> 1 year	22%	27%	0.5	0.3-0.9	0.02
Contraceptives:
never	84%	82%	1.0
ever	16%	18%	0.8	0.5-1.2	0.31
ever ≤ 2 years	6%	4%	0.9	0.5-1.5	0.67
ever > 2 years	2%	10%	0.8	0.5-1.4	0.47

CI - confidence interval; n - number of cases; OR - odds ratio; p - statistical significance.
^a - per additional year; ^b - per additional birth; ^c - prior to diagnosis of breast cancer.

ISSN: 1897-4287