Table 3 Cumulative risk of breast and ovarian cancer in mothers and sisters of probands with BRCA1 founder mutations
From: Selected aspects of genetic counselling for BRCA1 mutation carriers
Cancer site in relative | Type of relative | Number of first-degree relatives with cancer | Cancer risk to age of 50 | Cancer risk to age of 75 |
|---|---|---|---|---|
Breast | sisters | 57/356 | 0.27 | 0.42 |
| Â | mothers | 41/254 | 0.10 | 0.25 |
| Â | total | 100/851 | 0.18 | 0.33 |
Ovary | sisters | 18/356 | 0.06 | 0.21 |
| Â | mothers | 20/254 | 0.01 | 0.12 |
| Â | total | 38/1158 | 0.02 | 0.15 |