Selected aspects of genetic counselling for BRCA1 mutation carriers

Table 2 Cancer risk in relatives depending on type of mutation in proband

Mutation in proband	Breast cancer			Ovarian cancer			Any cancer
	RR	95% CI	p	RR	95% CI	p	RR	95% CI	p
5382insC (n = 557)	1.00			1.00			1.00
4153delA (n = 68)	1.12	0.53-2.34	0.77	1.85	0.77-4.47	0.17	1.17	0.68-2.01	0.58
C61G (n = 226)	1.44	0.93-2.21	0.10	0.28	0.09-0.93	0.04	1.28	0.92-1.78	0.15

RR - relative risk; CI - confidence interval; p - statistical significance; n - number of cases.

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