Selected aspects of genetic counselling for BRCA1 mutation carriers

Table 1 Estimated cumulative risk of breast, ovarian and other cancer in first-degree relatives of BRCA1 founder mutation carriers

Parameters	Cancer site in relative	*BRCA1* mutation type	First-degree relatives with cancer/total	Cancer risk to age of 50	Cancer risk to age of 75
Females	breast	5382insC	60/557	0.15	0.29
		C61G	32/226	0.23	0.46
		4153delA	8/68	0.25	0.25
		total	100/851	0.18	0.33
	ovary	5382insC	29/557	0.04	0.17
		C61G	3/226	0.01	0.05
		4153delA	6/68	0.08	0.38
		total	38/851	0.03	0.15
	other	5382insC	22/557	0.03	0.15
		C61G	17/226	0.05	0.36
		4153delA	1/68	0.02	0.02
		total	40/851	0.04	0.19
	any	5382insC	111/557	0.22	0.61
		C61G	52/226	0.29	0.87
		4153delA	15/68	0.36	0.66
		total	178/851	0.25	0.67
Males	any	5382insC	47/553	0.03	0.36
		C61G	16/193	0.05	0.33
		4153delA	7/70	0.00	0.39
		total	70/816	0.03	0.35

ISSN: 1897-4287