Skip to main content

Advertisement

Table 1 Genotype and allele distribution of variants in the ARLTS1 gene in BCC cases and controls

From: ARLTS1 polymorphisms and basal cell carcinoma of the skin

Genotype/Allele Cases* Controls OR (95%CI) P-value
S99S (297G>A)     
   GG 487 (92.2) 490 (91.9) 1.0 (referent)  
   GA 41 (7.7) 43 (8.1) 1.1 (0.7-1.7) 0.81**
   G-allele 1015 (96.1) 1023 (96.0) 1.0 (referent)  
   A-allele 41 (3.9) 43 (4.0) 1.1 (0.7-1.6) 0.81
P131L (392C>T)     
   CC 496 (93.9) 508 (95.3) 1.0 (referent)  
   CT 32 (6.1) 25 (4.7) 1.3 (0.8-2.3) 0.30
   C-allele 1024 (97.0) 1041 (97.7) 1.0 (referent)  
   T-allele 32 (3.0) 25 (2.3) 1.3 (0.8-2.3) 0.31
L132L (396G>C)     
   GG 527 (99.8) 531 (99.6) 1.0 (referent)  
   GC 1 (0.2) 2 (0.4) 0.4 (0.1-4.0) 0.40
   G-allele 1055 (99.9) 1064 (99.8) 1.0 (referent)  
   C-allele 1 (0.1) 2 (0.2) 0.4 (0.1-4.0) 0.40
C148R (442T>C)     
   TT 165 (31.3) 155 (29.1) 1.0 (referent)  
   TC 250 (47.4) 258 (48.4) 0.9 (0.7-1.2)  
   CC 113 (21.0) 120 (22.5) 0.9 (0.6-1.2) 0.64
   T-allele 580 (54.9) 568 (53.3) 1.0 (referent)  
   C-allele 476 (45.1) 498 (46.7) 0.9 (0.8-1.1) 0.36
W149X (446G>A)     
   GG 519 (98.3) 524 (98.3) 1.0 (referent)  
   GA 9 (1.7) 9 (1.7) 1.5 (0.6-4.0) 0.41
   G-allele 1047 (99.2) 1057 (99.2) 1.0 (referent)  
   A-allele 9 (0.8) 9 (0.8) 1.5 (0.5-3.5) 0.41
  1. *The number of cases and controls included in the study was 529 and 533, respectively. The sequencing for genotyping failed for one sample among cases.
  2. **Global P-values calculated from chi^2 test for genotype as a single event and allele effects were adjusted for age, gender and nationality.