A hypothesis-generating search for new genetic breast cancer syndromes - a national study in 803 Swedish families

Table 1 Observed numbers and proportions of non-breast cancer in the study families compared with statistics from 1958* and 1999*

Cancer site	Observed Number	Proportion [%]	LL** 95%	UL** 95%	Proportion [%] in Sweden 1958	Proportion [%] in Sweden 1999
Colon	204	11.958	10.418	13.498	8.70	8.89
Ovary/Fallopian tube	198	11.606	10.086	13.126	4.50	2.15
Endometrium	124	7.268	6.036	8.500	4.60	3.47
Pancreas	75	4.396	3.423	5.369	3.30	2.16
Liver	39	2.286	1.577	2.995	1.37	0.83
Leukaemia	77	4.513	3.528	5.499	3.50	2.67
Prostate	157	9.203	7.831	10.575	8.88	18.94
Stomach	104	6.096	4.961	7.231	14.48	2.85
Lung	90	5.275	4.215	6.336	5.60	7.63
Uterine cervix	76	4.455	3.476	5.434	5.30	1.16
Melanoma	66	3.869	2.954	4.784	1.10	4.12
Nervous system	66	3.869	2.954	4.784	3.66	3.50
Kidney	60	3.517	2.643	4.391	3.53	2.73
Rectum	58	3.400	2.540	4.260	5.81	4.87
All lymphomas/myelomas	51	2.989	2.181	3.798	4.02	5.67
Skin	42	2.462	1.727	3.197	2.99	7.11
Urinary tract	29	1.700	1.086	2.313	3.42	5.73
All non-Hodgkin's lymphoma	29	1.700	1.086	2.313	-	4.25
Thyroid gland	23	1.348	0.801	1.895	1.03	0.67
Conn. tissue	21	1.231	0.708	1.754	0.70	0.77
Oesophagus	20	1.172	0.662	1.683	1.10	1.04
Larynx	18	1.055	0.570	1.540	0.60	0.47
Mouth/Lip/Tongue	17	0.996	0.525	1.468	1.67	1.27
Myelomas	17	0.996	0.525	1.468	-	1.43
Biliary tract	15	0.879	0.436	1.322	1.26	1.11
Mouth	11	0.645	0.265	1.025	-	0.50
Small intestine	10	0.586	0.224	0.948	0.33	0.52
Bone	8	0.469	0.200	0.920	0.53	0.15
Testis	7	0.410	0.170	0.840	0.50	0.66
Vulva/Vagina	7	0.410	0.170	0.840	0.73	0.52
Hodgkin's lymphoma	5	0.293	0.100	0.680	-	0.45
Salivary gland	5	0.293	0.100	0.680	0.31	0.25
Adrenal gland	4	0.234	0.060	0.600	-	-
Pharynx	4	0.234	0.060	0.600	0.71	0.58
Lip	4	0.234	0.060	0.600	-	0.42
Nose/Sinuses	3	0.176	0.040	0.510	0.49	0.15
Tongue	2	0.117	0.010	0.420	-	0.36

*Cancer incidence in Sweden 1958 and 1999: Swedish National Board of Health and Welfare 1958 and 1999 respectively.
**Lower Limit [LL] Upper Limit [UL].
If the 95% CI covers the proportion from 1958 (or 1999), no significant difference from that year can be demonstrated
When the observed frequency is less than 10 an exact confidence interval for the proportion is calculated.
Diagnoses in bold indicate a type of tumour in study families with a proportion with 95% CI that does not cover the proportion demonstrated in the Swedish Cancer registry in both 1958 and 1999.

ISSN: 1897-4287