Table 2 Park I criteria for suspected HNPCC families (according to [16]*). At least one item in each category must be met (A or B) and (C or D or E)
From: Some aspects of molecular diagnostics in Lynch syndrome
Category I | Category II |
|---|---|
A - vertical transmission of colorectal cancer | C - multiple colorectal tumours (including polyps) |
B - at least two siblings affected with colorectal cancer in a family | D - at least one colorectal cancer diagnosed before the age of 50 years |
- | E - development of extracolonic cancer (endometrium, small intestine, urinary tract, stomach, hepatobiliary system or ovary) in family members |