Table 1 Diagnostic criteria of HNPCC according to ICG-HNPCC
From: Some aspects of molecular diagnostics in Lynch syndrome
Amsterdam criteria I | Amsterdam criteria II |
|---|---|
Colorectal cancer confirmed histologically in at least three affected relatives, one of whom is a first-degree relative of the other two | Cancer1 confirmed histologically in at least three affected relatives, one of whom is a first-degree relative of the other two |
At least two first-degree relatives in two successive generations | At least two first-degree relatives in two successive generations |
At least one member diagnosed with colorectal cancer before age 50 years | At least one member diagnosed with cancer1 before age 50 years |
Familial adenomatous polyposis has been excluded | Familial adenomatous polyposis has been excluded |