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Table 1 [6] Relative risk and odds ratios of cancers seen in HNPCC families

From: Cancer Genetics Group Spring Meeting. 22 & 23 May, 2006. Birmingham, U.K

Tumour Type Number of Cancers Familial Relative Risk Odds Ratio
  MLH1 MSH2 MSH6 total MLH1 MSH2 total MLH1 MSH2 total
colorectal 301 262 14 577 - - - 36.0 44.1 36.9
colorectal <40 years 71 58 1 130 *2.2 0.8 1.3 500.4 575.3 490.3
non-colorectal <40 22 24 2 48 2.1 1.0 1.3 4.6 7.1 5.4
endometrial 39 58 9 106 *2.7 ***5.6 ***3.6 25.3 52.9 36.7
gastric 25 25 3 53 1.2 *2.7 1.5 10.0 14.1 11.4
breast 21 16 2 39 1.2 0.4 0.7 1.7 1.8 1.7
renal 5 30 2 37 - ***7.4 ***4.3 2.9 24.6 11.6
ureter 0 13 0 13 - **9.9 - 0.0 292.9 111.4
bladder 4 9 0 13 16.8 2.0 3.7 1.0 3.1 1.7
ovary 8 19 0 27 0.0 2.3 1.7 3.9 13.0 7.0
pancreas 12 9 1 22 *5.7 2.2 *3.8 7.2 7.6 7.1
skin 8 17 1 26 2.7 *4.2 *3.3 - - -
sebaceous adenoma 3 6 0 9 *45.6 *24.4 ***29.0 - - -
sarcoma 4 4 0 8 13.8 ***68.1 ***26.7 7.6 10.7 8.1
small intestine 3 4 0 7 - - - 19.8 37.1 24.7
biliary tract 2 0 0 2 - - - 6.8 0.0 3.6
other 38 27 6 71 - - - 1.0 1.0 1.0
total 470 480 38 988