Table 1 [6] Relative risk and odds ratios of cancers seen in HNPCC families
From: Cancer Genetics Group Spring Meeting. 22 & 23 May, 2006. Birmingham, U.K
Tumour Type | Number of Cancers | Familial Relative Risk | Odds Ratio | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | MLH1 | MSH2 | MSH6 | total | MLH1 | MSH2 | total | MLH1 | MSH2 | total |
colorectal | 301 | 262 | 14 | 577 | - | - | - | 36.0 | 44.1 | 36.9 |
colorectal <40 years | 71 | 58 | 1 | 130 | *2.2 | 0.8 | 1.3 | 500.4 | 575.3 | 490.3 |
non-colorectal <40 | 22 | 24 | 2 | 48 | 2.1 | 1.0 | 1.3 | 4.6 | 7.1 | 5.4 |
endometrial | 39 | 58 | 9 | 106 | *2.7 | ***5.6 | ***3.6 | 25.3 | 52.9 | 36.7 |
gastric | 25 | 25 | 3 | 53 | 1.2 | *2.7 | 1.5 | 10.0 | 14.1 | 11.4 |
breast | 21 | 16 | 2 | 39 | 1.2 | 0.4 | 0.7 | 1.7 | 1.8 | 1.7 |
renal | 5 | 30 | 2 | 37 | - | ***7.4 | ***4.3 | 2.9 | 24.6 | 11.6 |
ureter | 0 | 13 | 0 | 13 | - | **9.9 | - | 0.0 | 292.9 | 111.4 |
bladder | 4 | 9 | 0 | 13 | 16.8 | 2.0 | 3.7 | 1.0 | 3.1 | 1.7 |
ovary | 8 | 19 | 0 | 27 | 0.0 | 2.3 | 1.7 | 3.9 | 13.0 | 7.0 |
pancreas | 12 | 9 | 1 | 22 | *5.7 | 2.2 | *3.8 | 7.2 | 7.6 | 7.1 |
skin | 8 | 17 | 1 | 26 | 2.7 | *4.2 | *3.3 | - | - | - |
sebaceous adenoma | 3 | 6 | 0 | 9 | *45.6 | *24.4 | ***29.0 | - | - | - |
sarcoma | 4 | 4 | 0 | 8 | 13.8 | ***68.1 | ***26.7 | 7.6 | 10.7 | 8.1 |
small intestine | 3 | 4 | 0 | 7 | - | - | - | 19.8 | 37.1 | 24.7 |
biliary tract | 2 | 0 | 0 | 2 | - | - | - | 6.8 | 0.0 | 3.6 |
other | 38 | 27 | 6 | 71 | - | - | - | 1.0 | 1.0 | 1.0 |
total | 470 | 480 | 38 | 988 | Â | Â | Â | Â | Â | Â |