Selected Aspects of Molecular Diagnostics of Constitutional Alterations in BRCA1 and BRCA2 Genes Associated with Increased Risk of Breast Cancer in the Polish Population

Table 7 Prevalence of C5972T polymorphism in the group of unselected breast cancers diagnosed prior to 50 years of age and in the control group

Parameters	Control group	Breast cancers	Odds ratio	p-value	95%CI
all cancer cases
CC	2630	3039	1.0
CT	159	191	1.0	0.74	0.8-1.3
TT	2	11	4.8	0.02	1.1-21.4
CT+TT	161	202	1.1	0.45	0.9-1.3
total	2791	3241
cancer diagnosed prior to 40 years of age
CC	2630	598	1.0
CT	159	51	1.4	0.04	1.0-2.0
TT	2	1	2.2	0.46	0.2-23.7
CT+TT	161	52	1.4	0.03	1.0-1.9
total	2791	650
cancer diagnosed past 41 years of age
CC	2630	2441	1.0
CT	159	140	0.9	0.68	0.8-1.2
TT	2	10	5.4	0.02	1.2-24.6
CT+TT	161	150	1.0	0.97	0.8-1.3
total	2791	2591

ISSN: 1897-4287