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Table 6 Nature of BRCA1/2 deleterious mutations and factors associated with deleterious BRCA1/2 mutation (n = 17)

From: Establishing a Cancer Genetics Programme in Asia - the Singapore Experience

 

Percentage

nature of deleterious mutation

   frameshift

59

   nonsense

23

   large deletions/rearrangements

18

probability of identifying deleterious BRCA1/2 mutation based on risk profile

   cancer patient with family history of breast and ovarian cancer (n = 13)

54

   cancer patient with family history of breast cancer (n = 12)

50

   young onset breast cancer without family history of cancer (n = 25)

16

   male breast cancer/bilateral breast cancer (n = 3)

0