Establishing a Cancer Genetics Programme in Asia - the Singapore Experience

Table 3 Characteristics of patients reviewed in the cancer genetics clinic (n = 367)

age
median (range)	39 (17-80)
ethnic group
Chinese	78%
Malay	11%
Indian	4%
others	7%
index patient has cancer	74%
risk categories
breast cancer-related cases (n = 219)
low risk (<10%) for hereditary breast cancer (HBC) syndrome	12%
modest risk (10-20%) for HBC syndrome	65%
moderate risk (20-40%) for HBC syndrome	11%
high risk (>40%) for HBC syndrome^a	12%
colorectal cancer-related cases (n = 114)
low risk (<10%) for hereditary colorectal cancer (HCRC) syndrome	4%
modest risk (10-20%) for HCRC syndrome	61%
moderate risk (20-40%) for HCRC syndrome	24%
high risk (>40%) for HCRC syndrome^b	11%
others (n = 34)^c
familial clustering of stomach cancers/young stomach cancers	35%
familial cancer clustering in a pattern not distinctive of known hereditary cancer syndromes	30%
others^d	35%

^ainclude 10 patients counselled for predictive testing for a familial mutation; ^binclude 1 patient counselled for predictive testing for a familial mutation; ^c18 patients were deemed to have at least 10% chance of having a known hereditary cancer syndrome and offered genetic counselling and testing; ^dfamilial clustering of or young nasopharyngeal cancers (9%), familial clustering of renal cancers (9%), suspected Li Fraumeni syndrome (6%), familial clustering of paragangliomas suspicious of SDHD mutations (3%), multiple endocrine neoplasia IIA (3%), suspected neurofibromatosis (3%), Turner's syndrome with young endometrial cancer (3%)

ISSN: 1897-4287