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Table 3 Occurrence of MTC related to patient characteristics and type of RET gene mutation in children who underwent prophylactic thyroidectomy for multiple endocrine neoplasia type 2A

From: An Introduction to Managing Medullary Thyroid Cancer

Patient/family Year of surgery Sex Age (year) Type of RET mutation Calcitonin (ng/L) Basal/Stimulateda Lymph node dissection (initially) Histology
1/A 1976 M 17 M918Tb - central and unilateral (level II-V) multifocal MTC; positive lymph nodes
2/B 1998 F 18 C634G 2000/31600 central multifocal MTC; positive lymph nodes
3/C 1999 M 14 C634R 151/1200 central multifocal MTC; positive lymph nodes
4/D 1977 F 18 C634R - central multifocal MTC
5/D 1978 M 17 C634R 489/- central multifocal MTC
6/E 1995 F 5 C634R 61/198 central exploration multifocal MTC
7/C 1999 F 12 C634R 12/125 central exploration multifocal MTC
8/F 2000 F 5 C634Y 34/- central exploration multifocal MTC
9/B 2004 F 3 C634G 72/188 central multifocal MTC
10/G 2005 F 11 C634R 13/- central multifocal MTC
11/F 1995 F 11 C634Y 24/122 central exploration unifocal MTC
12/H 1999 M 4 C634R 5/384 - unifocal MTC
13/I 2000 F 6 C620R 15/- central unifocal MTC
14/J 1995 F 4 C634W/R635G 18/447 central unifoclal MTC
15/J 1990 F 14 C634W/R635G 632/- - CCH
16/K 1990 F 7 C634R 63/- central exploration CCH
17/K 1990 M 10 C634R 92/- central CCH
18/F 1995 M 11 C634Y 79/177 central exploration CCH
19/F 2004 F 1 C634Y 48/- central CCH
20/L 2005 M 16 V804L 13/32 central CCH
21/I 1997 F 5 C620R 13/- - no C-cell disease
  1. abefore 2001 the reference value was <50 ng/L, after 2001 the reference value was <12 ng/L;
  2. bpatient with multiple endocrine neoplasia type 2B;
  3. RET - rearranged during transfection; F - female; CCH - C-cel hyperplasia; M - male; MTC - medullary thyroid carcinoma