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Table 3 Occurrence of MTC related to patient characteristics and type of RET gene mutation in children who underwent prophylactic thyroidectomy for multiple endocrine neoplasia type 2A

From: An Introduction to Managing Medullary Thyroid Cancer

Patient/family

Year of surgery

Sex

Age (year)

Type of RET mutation

Calcitonin (ng/L) Basal/Stimulateda

Lymph node dissection (initially)

Histology

1/A

1976

M

17

M918Tb

-

central and unilateral (level II-V)

multifocal MTC; positive lymph nodes

2/B

1998

F

18

C634G

2000/31600

central

multifocal MTC; positive lymph nodes

3/C

1999

M

14

C634R

151/1200

central

multifocal MTC; positive lymph nodes

4/D

1977

F

18

C634R

-

central

multifocal MTC

5/D

1978

M

17

C634R

489/-

central

multifocal MTC

6/E

1995

F

5

C634R

61/198

central exploration

multifocal MTC

7/C

1999

F

12

C634R

12/125

central exploration

multifocal MTC

8/F

2000

F

5

C634Y

34/-

central exploration

multifocal MTC

9/B

2004

F

3

C634G

72/188

central

multifocal MTC

10/G

2005

F

11

C634R

13/-

central

multifocal MTC

11/F

1995

F

11

C634Y

24/122

central exploration

unifocal MTC

12/H

1999

M

4

C634R

5/384

-

unifocal MTC

13/I

2000

F

6

C620R

15/-

central

unifocal MTC

14/J

1995

F

4

C634W/R635G

18/447

central

unifoclal MTC

15/J

1990

F

14

C634W/R635G

632/-

-

CCH

16/K

1990

F

7

C634R

63/-

central exploration

CCH

17/K

1990

M

10

C634R

92/-

central

CCH

18/F

1995

M

11

C634Y

79/177

central exploration

CCH

19/F

2004

F

1

C634Y

48/-

central

CCH

20/L

2005

M

16

V804L

13/32

central

CCH

21/I

1997

F

5

C620R

13/-

-

no C-cell disease

  1. abefore 2001 the reference value was <50 ng/L, after 2001 the reference value was <12 ng/L;
  2. bpatient with multiple endocrine neoplasia type 2B;
  3. RET - rearranged during transfection; F - female; CCH - C-cel hyperplasia; M - male; MTC - medullary thyroid carcinoma