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Table 1 Clinical expression of the variants of hereditary MTC associated syndromes

From: An Introduction to Managing Medullary Thyroid Cancer

 

FMTC

MEN 2A

MEN 2B

medullary thyroid cancer

100%

100%

100%

C-cell hyperplasia

100%

100%

100%

Pheochromocytoma

0%

10% to 60%

50%

Hyperparathyroidism

0%

10% to 25%

0%

Marfanoid habitus

0%

0%

100%

Intestinal ganglioneuromatosis

0%

0%

60% to 90%

Mucosal neuromas

0%

0%

70% to 100%

thick corneal nerves

0%

Rare

60% to 90%

  1. FMTC, familial medullary thyroid cancer; MEN 2A/2B, multiple endocrine neoplasia type 2A/2B