Figure 4

Cluster analysis of neurological symptoms present in control and XP complementation groups. A comparison of control and XP complementation group with presence/absence of neurological symptoms and gene expression. Control and XP fibroblasts cell line cultures were exposed to UV light. Each column represents expression in each of the cell lines of 383 genes significantly differentially expressed in XP complementation groups with and without neurological symptoms. Down-regulation is represented as green, up-regulation as red and normal expression as yellow. The dendrogram on top represents the relationship between and within the two groups; blue branches represent absence and red branches represent presence of neurological symptoms. The dendrogram on the side represents relatedness of genes based on expression levels. A cluster of red branches is clearly depicted in the top dendrogram indicating a distinct gene expression profile for the presence of neurological symptoms in XP