Population Screening for Cancer Family Syndromes in the West Pomeranian Region of Poland
© The Author(s) 2006
Received: 19 December 2005
Accepted: 10 January 2006
Published: 15 January 2006
Hereditary breast/ovarian cancer syndrome - 4121 families including 438 families with diagnosed BRCA1/2 mutation.
- 2.Familial syndromes of colorectal cancer:
HNPCC - 568 families including 63 families with diagnosed MSH2/MLH1 mutation,
FAP - 22 families,
Late onset colorectal cancer aggregations - 459 families.
- 3.Other hereditary organ specific syndromes:
hereditary stomach cancer - 1250 families,
hereditary renal cancer - 565 families,
hereditary laryngeal cancer - 206 families,
hereditary prostate cancer - 170 families,
NFI - 66 families,
VHL - 36 families,
Retinoblastoma - 4 families,
Peutz Jeghers syndrome - 3 families,
juvenile polyposis - 2 families.
- 4.Organ-specific familial aggregations:
familial lung cancer - 242 families,
familial leukaemia/lymphoma - 77 families,
familial liver cancer - 68 families,
familial cervical cancer - 30 families,
familial pancreatic cancer - 73 families,
familial melanoma - 44 families,
familial bladder - 19 families.
Unspecified cancer family aggregations - 3319 families.
Appropriate management has been introduced in all identified families with high predisposition to malignancies.