Table 3 Association between CHEK2 variants and selected types of cancer
From: Low-risk Genes and Multi-organ Cancer Risk in the Polish Population
Site | No. tested | Number positive (prevalence), odds ratio, p-value | |||
|---|---|---|---|---|---|
IVS2 + 1G>A | 1100delC | Any truncating mutation | I157T | ||
bladder | 172 | 1 (0.6%) OR 1.2 p = 0.7 | 0 | 1 (0.6%) OR 0.8 p = 0.8 | 12 (7.0%) OR 1.5 p = 0.3 |
breast | 1017 | 11 (1.1%) OR 2.3 p = 0.04 | 5 (0.5%) OR 2.0 p = 0.3 | 16 (1.6%) OR 2.2 p = 0.02 | 68 (6.7%) OR 1.4 p = 0.02 |
colon | 300 | 1 (0.3%) OR 0.7 p = 0.9 | 2 (0.7%) OR 2.7 p = 0.4 | 3 (1%) OR 1.4 p = 0.8 | 28 (9.3%) OR 2.0 p = 0.001 |
kidney | 264 | 0 | 2 (0.8%) OR 2.7 p = 0.5 | 2 (0.8%) OR 1.0 p = 0.8 | 26 (9.8%) OR 2.1 p = 0.0006 |
larynx | 245 | 0 | 0 | 0 | 10 (4.1%) OR 0.8 p = 0.7 |
lung | 272 | 0 | 0 | 0 | 7 (2.6%) OR 0.5 p = 0.1 |
melanoma | 129 | 2 (1.5%) OR 3.3 p = 0.3 | 1 (0.8%) OR 3.1 p = 0.8 | 3 (2.3%) OR 3.2 p = 0.1 | 6 (4.6%) OR 1.0 p = 0.9 |
ovary | 292 | 0 | 0 | 0 | 14 (4.8%) OR 1.0 p = 0.9 |
prostate | 690 | 8 (1.2%) OR 2.5 p = 0.05 | 3 (0.4%) OR 1.7 p = 0.2 | 11 (1.6%) OR 2.2 p = 0.04 | 54 (7.8%) OR 1.7 p = 0.002 |
stomach | 241 | 4 (1.7%) OR 3.5 p = 0.05 | 0 | 4 (2.1%) OR 2.3 p = 0.2 | 13 (5.4%) OR 1.1 p = 0.8 |
NHL | 120 | 1 (0.8%) OR 1.8 p = 0.9 | 0 | 1 (0.8%) OR 1.1 p = 0.7 | 11 (9.2%) OR 2.0 p = 0.05 |
pancreas | 93 | 0 | 0 | 0 | 6 (6.4%) OR 1.4 p = 0.6 |
thyroid | 173 | 5 (2.9%) OR 6.2 p = 0.0003 | 1 (0.6%) OR 2.3 p = 0.9 | 6 (3.5%) OR 4.9 p = 0.0006 | 15 (8.7%) OR 1.9 p = 0.04 |
controls | 4000 | 19 (0.475%) | 10 (0.25%) | 29 (0.725%) | 193 (4.825%) |