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Table 3 Association between CHEK2 variants and selected types of cancer

From: Low-risk Genes and Multi-organ Cancer Risk in the Polish Population

Site No. tested Number positive (prevalence), odds ratio, p-value
   IVS2 + 1G>A 1100delC Any truncating mutation I157T
bladder 172 1 (0.6%) OR 1.2 p = 0.7 0 1 (0.6%) OR 0.8 p = 0.8 12 (7.0%) OR 1.5 p = 0.3
breast 1017 11 (1.1%) OR 2.3 p = 0.04 5 (0.5%) OR 2.0 p = 0.3 16 (1.6%) OR 2.2 p = 0.02 68 (6.7%) OR 1.4 p = 0.02
colon 300 1 (0.3%) OR 0.7 p = 0.9 2 (0.7%) OR 2.7 p = 0.4 3 (1%) OR 1.4 p = 0.8 28 (9.3%) OR 2.0 p = 0.001
kidney 264 0 2 (0.8%) OR 2.7 p = 0.5 2 (0.8%) OR 1.0 p = 0.8 26 (9.8%) OR 2.1 p = 0.0006
larynx 245 0 0 0 10 (4.1%) OR 0.8 p = 0.7
lung 272 0 0 0 7 (2.6%) OR 0.5 p = 0.1
melanoma 129 2 (1.5%) OR 3.3 p = 0.3 1 (0.8%) OR 3.1 p = 0.8 3 (2.3%) OR 3.2 p = 0.1 6 (4.6%) OR 1.0 p = 0.9
ovary 292 0 0 0 14 (4.8%) OR 1.0 p = 0.9
prostate 690 8 (1.2%) OR 2.5 p = 0.05 3 (0.4%) OR 1.7 p = 0.2 11 (1.6%) OR 2.2 p = 0.04 54 (7.8%) OR 1.7 p = 0.002
stomach 241 4 (1.7%) OR 3.5 p = 0.05 0 4 (2.1%) OR 2.3 p = 0.2 13 (5.4%) OR 1.1 p = 0.8
NHL 120 1 (0.8%) OR 1.8 p = 0.9 0 1 (0.8%) OR 1.1 p = 0.7 11 (9.2%) OR 2.0 p = 0.05
pancreas 93 0 0 0 6 (6.4%) OR 1.4 p = 0.6
thyroid 173 5 (2.9%) OR 6.2 p = 0.0003 1 (0.6%) OR 2.3 p = 0.9 6 (3.5%) OR 4.9 p = 0.0006 15 (8.7%) OR 1.9 p = 0.04
controls 4000 19 (0.475%) 10 (0.25%) 29 (0.725%) 193 (4.825%)