Figure 2

Time sequence of the growth of the sample database (dashed line) in number of patients (note: the number of genotyped samples is actually 3500) and the improvement of the coverage of disease-associated genetic factors in the same population (continuous line). The percentage of coverage is based on estimations for different numbers of patients depending on the specific genes involved: 3000 patients for BRCA1, BRCA2, CHEK2, NBS1, NOD2 and P16; and 850 patients for those genes and the ones referred as X1, X2 and X3 (currently under study). The approximately onset of systematic analyses for the respective genes is indicated with an arrow and the gene's acronym