Table 2 Persons eligible for VHL gene germline mutation analysis

1. A patient with classic VHL disease (meeting clinical diagnostic criteria) and/or first degree family members

2. A person from a family in which a germline VHL gene mutation has been identified (presymptomatic test)

3. A VHL-suspected patient, i.e.:

   - multicentric VHL tumours in one organ,

   - bilateral VHL tumours,

   - two or more VHL organ systems affected,

   - one VHL-associated tumour at a young age (i.e. <50 years for haemangioblastoma and phaeochromocytoma and <30 years for renal cell carcinoma)

4. A patient from a family with haemangioblastoma, renal cell carcinoma or phaeochromocytoma only