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Figure 2 | Hereditary Cancer in Clinical Practice

Figure 2

From: Von Hippel-Lindau Disease

Figure 2

Functional domains of the VHL protein and distribution of germline mutations (from VHL database) [22]. Hotspots for mutations are readily visible at amino acids 67-117, hypoxia-inducible factor (HIF)-1α binding domain (in the β-domain) and 157-170, Elongin C (EloC) binding domain (in the α-domain). Copyright 2003, The Endocrine Society [16]

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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287