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Table 2 Clinical Surveillance Protocol for Carriers of Germline Mismatch Repair Gene Mutation

From: Hereditary Colorectal Cancer Syndromes in Hong Kong: a Registry's Perspective

 

Starting age (year)

Interval (year)

Method

colorectal

25

age 25-35:2 years

colonoscopy

  

age >35:1 year

 

gynaecological

25

age 25-35:3 years

vaginal examination, endometrial aspiration,

  

age >35:2 years

trans-abdominal/trans-vaginal ultrasound, serum ovarian tumour marker

urological

25

age 25-35: 3 years

urine cytology, ultrasound kidneys & bladder

  

age >35:2 years

 

gastric (if positive family history)

25

age 25-35: 3 years

upper endoscopy

  

age >35:2 years

 
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Hereditary Cancer in Clinical Practice

ISSN: 1897-4287